Karin J Neufeld, MD, MPH
Disclosures: Nothing to disclose - 05/06/2022
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OMB No. 0925-0001 and 0925-0002 (Rev. 10/2021 Approved Through 09/30/2024)


BIOGRAPHICAL SKETCH

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NAME: Neufeld, Karin

eRA COMMONS USER NAME (credential, e.g., agency login): kneufel2

POSITION TITLE: Professor

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)

INSTITUTION AND LOCATION

DEGREE
(if applicable)

END DATE
MM/YYYY

FIELD OF STUDY

University of Manitoba, Winnipeg, Manitoba

BS

05/1986

Medicine

University of Manitoba School of Medicine, Winnipeg, MB

MD

05/1986

Medicine

Johns Hopkins University School of Public Health, Baltimore, MD

MPH

05/1992

Psychiatric Epidemiology

McGill University School of Medicine, Montreal, Quebec

Resident

06/1987

Rotating Internship

Johns Hopkins University School of Medicine, Baltimore, MD

Resident

06/1991

Residency in General Adult Psychiatry

Johns Hopkins University School of Medicine, Baltimore, MD

Fellow

06/1993

Fellowship in Community Psychiatry

A. Personal Statement

This important independent scientist career development grant will enhance the principal investigator's experience and training in the study of dementia and cognitive decline in kidney transplant (KT) candidates undergoing dialysis and older KT recipients. Given the impact of perioperative delirium on future development of dementia, my role as a consultant in this protocol will include responsibility for leading delirium training. MyI have substantial expertise in delirium measurement is as demonstrated by my leadership as a single PI on a NIH-funded randomized controlled trial of a melatonin agonist (ramelteon) in preventing postoperative delirium in older adults (R21AG050850), by my involvement in NIH-funded randomized controlled trials in which I was responsible for chairing the Delirium Diagnostic Consensus Panel, leading the standardized delirium diagnostic teams, and designing and providing oversight of the delirium diagnostic quality assurance process (R01AG033615; PI Sieber; R01HL092259; PI Hogue R01AG068004; PI Brown). As PI, I have completed two delirium observational measurement protocols in inpatient clinical settings; the latter included the study of over 100 consenting older patients undergoing surgery with general anesthesia and followed longitudinally for 18 months (See C.1). My collaborative leadership is evident from my role as the founding Chair of the Johns Hopkins Delirium Consortium in which I lead a diverse group of clinicians and researchers to advance delirium care and research. I am a nationally and internationally recognized delirium researcher, having served on the American Geriatric Society Expert Panel for Postoperative Delirium, the 2018 Society of Critical Care Medicine Pain, Agitation, Delirium, Early Mobilization and Sleep Guideline Panel and recently as the Co-Lead for the AHRQ-funded report on antipsychotic use in treating and preventing delirium. I am Past President of the American Delirium Society. I have extensively collaborated with most of the clinical research team involved in this STTR proposal. My expertise in delirium measurement, and a proven record of leadership and collaboration with a team of productive clinician-researchers will allow me to support this important STTR proposal. be a successful Consultant on the proposed grant.

1.      Nikooie R, Neufeld KJ, Oh ES, Wilson LM, Zhang A, Robinson KA, Needham DM. Antipsychotics for Treating Delirium in Hospitalized Adults: A Systematic Review. Ann Intern Med. 2019 Oct 1;171(7):485-495. PubMed PMID: 31476770.

2.      Oh ES, Needham DM, Nikooie R, Wilson LM, Zhang A, Robinson KA, Neufeld KJ. Antipsychotics for Preventing Delirium in Hospitalized Adults: A Systematic Review. Ann Intern Med. 2019 Oct 1;171(7):474-484. PubMed PMID: 31476766.

3.      Neufeld KJ, Needham DM, Oh ES, Wilson LM, Nikooie R, Zhang A, Koneru M, Balagani A, Singu S, Aldabain L, Robinson KA. Antipsychotics for the Prevention and Treatment of Delirium [Internet] Rockville (MD): Agency for Healthcare Research and Quality (US); 2019Sep. Available from: http://www.ncbi.nlm.nih.gov/books/NBK546180/ PubMed PMID: 31509366

4.      Neufeld KJ, Yue J, Robinson TN, Inouye SK, Needham DM. Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis. J Am Geriatr Soc. 2016 Apr;64(4):705-14. PubMed Central PMCID: PMC4840067.

B. Positions, Scientific Appointments and Honors

Positions and Scientific Appointments

2020 -

Professor, Johns Hopkins University School of Medicine, Baltimore, MD

2014 -

Clinical Director of Psychiatry, Johns Hopkins Bayview Medical Center, Baltimore , MD

2014 -

Director of the Behavioral Health Consultation Service, Johns Hopkins Bayview Medical Center, Baltimore, MD

2011 - 2020

Associate Professor Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD

2008 - 2014

Director of Inpatient Psychiatric Consultation Services, The Johns Hopkins Hospital, Baltimore, MD

2001 - 2008

Associate Medical Director, Addiction Treatment Services, Baltimore, MD

1998 - 2001

Visiting Scientist and Guest Faculty - Department of Psychiatry, All India Institute of Medical Sciences, New Delhi

1996 - 2011

Assistant Professor Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD

1995 - 1998

Co-Director, Schizophrenia Clinic, Community Psychiatry , The Johns Hopkins Hospital, Baltimore, MD

1993 - 1996

Instructor Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD

Honors

2019

Plenary Address, Meeting of the Royal College of Physician and Surgeons of Edinburgh

2017

Keynote Speaker, European Delirium Association Annual Meeting

2015

Dean's Leadership Program , Johns Hopkins University School of Medicine

2013

Pain, Agitation, Delirium, Early Mobilization and Sedation Guideline Expert Panel Membership, Society of Critical Care Medicine

2013

President , American Delirium Society

2013

Postoperative Delirium Prevention and Treatment Panel Expert: Pharmacologic Treatment Section Leader, American Geriatrics Society

2009

Leadership Program for Women Faculty, Johns Hopkins University School of Medicine

2009

Chester W. Schmidt, Jr. Teaching Award, Johns Hopkins University School of Medicine

2008

Chester W. Schmidt, Jr. Teaching Award, Johns Hopkins University School of Medicine

C. Contribution to Science

1.                  Measurement of Delirium: My contributions to the measurement of delirium include psychometric study of properties of various measures to detect delirium in different clinical populations. I have demonstrated that measures used in critically ill patients (such as the Confusion Assessment Method –Intensive Care Unit or CAM-ICU version) is not sensitive enough for populations of non-critically ill patients nor is the former instrument sensitive enough for use in the Post Anesthesia Care Unit (PACU) in to detecting delirium in older postoperative patients. In a separate examination of the reference standard practices in delirium research, I have demonstrated the significant heterogeneity of current practice in establishing a diagnosis of delirium. This work highlights the need for much more rigorous and standardized approaches to delirium measurement particularly in research, but also in clinical practice – which is one area of expertise that I bring to all related research studies that I am involved in.

a.                              Tieges Z, Evans JJ, Neufeld KJ, MacLullich AMJ. The neuropsychology of delirium: advancing the science of delirium assessment. Int J Geriatr Psychiatry. 2018 Nov;33(11):1501-1511. PubMed Central PMCID: PMC6704364.

b.                              Neufeld KJ, Nelliot A, Inouye SK, Ely EW, Bienvenu OJ, Lee HB, Needham DM. Delirium diagnosis methodology used in research: a survey-based study. Am J Geriatr Psychiatry. 2014 Dec;22(12):1513-21. PubMed Central PMCID: PMC4164600.

c.                              Neufeld K, Leoutsakos J, Sieber F, Joshi D, Wanamaker B, Rios-Robles J, Needham D. Evaluation of two delirium screening tools for detecting post-operative delirium in the elderly. British Journal of Anaesthesia. 2013 October; 111(4):612-618. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0007091217323553 DOI: 10.1093/bja/aet167

d.                              Neufeld KJ, Hayat MJ, Coughlin JM, Huberman AL, Leistikow NA, Krumm SK, Needham DM. Evaluation of two intensive care delirium screening tools for non-critically ill hospitalized patients. Psychosomatics. 2011 Mar-Apr;52(2):133-40. PubMed PMID: 21397105.

2.                  Epidemiology of Delirium in Critical Care and Postoperative Settings: My work in the critical care and postoperative settings has included understanding the risk factors associated with development of delirium and the development of interventions that prevent its occurrence in intensive care settings (i.e. protocols that enhance sleep in the intensive care unit, sedation interruption and reduction, corticosteroid exposure). My role in these studies has been to provide expert clinical judgment to the development of clinical protocols and to ensure best practices in delirium detection.

a.                              Neufeld KJ, Leoutsakos JS, Yan H, Lin S, Zabinski JS, Dinglas VD, Hosey MM, Parker AM, Hopkins RO, Needham DM. Fatigue Symptoms During the First Year Following ARDS. Chest. 2020 Sep;158(3):999-1007. PubMed Central PMCID: PMC7478232.

b.                              Hosey MM, Leoutsakos JS, Li X, Dinglas VD, Bienvenu OJ, Parker AM, Hopkins RO, Needham DM, Neufeld KJ. Screening for posttraumatic stress disorder in ARDS survivors: validation of the Impact of Event Scale-6 (IES-6). Crit Care. 2019 Aug 7;23(1):276. PubMed Central PMCID: PMC6686474.

c.                              Neufeld KJ, Leoutsakos JM, Oh E, Sieber FE, Chandra A, Ghosh A, Schretlen DJ, Needham DM. Long-Term Outcomes of Older Adults with and Without Delirium Immediately After Recovery from General Anesthesia for Surgery. Am J Geriatr Psychiatry. 2015 Oct;23(10):1067-74. PubMed PMID: 25912784.

d.                              Neufeld KJ, Leoutsakos JM, Sieber FE, Wanamaker BL, Gibson Chambers JJ, Rao V, Schretlen DJ, Needham DM. Outcomes of early delirium diagnosis after general anesthesia in the elderly. Anesth Analg. 2013 Aug;117(2):471-8. PubMed Central PMCID: PMC4017627.

3.                  Pharmacologic Prevention and Treatment of Delirium: In addition to the epidemiology and measurement of delirium, my work has also included the elucidation of the role of pharmacologic strategies in the prevention and treatment of delirium. This work has focused on a number of drug classes including antipsychotic medications.

a.                              Nikooie R, Neufeld KJ, Oh ES, Wilson LM, Zhang A, Robinson KA, Needham DM. Antipsychotics for Treating Delirium in Hospitalized Adults: A Systematic Review. Ann Intern Med. 2019 Oct 1;171(7):485-495. PubMed PMID: 31476770.

b.                              Oh ES, Needham DM, Nikooie R, Wilson LM, Zhang A, Robinson KA, Neufeld KJ. Antipsychotics for Preventing Delirium in Hospitalized Adults: A Systematic Review. Ann Intern Med. 2019 Oct 1;171(7):474-484. PubMed PMID: 31476766.

c.                              Neufeld KJ, Needham DM, Oh ES, Wilson LM, Nikooie R, Zhang A, Koneru M, Balagani A, Singu S, Aldabain L, Robinson KA. Antipsychotics for the Prevention and Treatment of Delirium [Internet] Rockville (MD): Agency for Healthcare Research and Quality (US); 2019Sep. Available from: http://www.ncbi.nlm.nih.gov/books/NBK546180/ PubMed PMID: 31509366

d.                              Neufeld KJ, Yue J, Robinson TN, Inouye SK, Needham DM. Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis. J Am Geriatr Soc. 2016 Apr;64(4):705-14. PubMed Central PMCID: PMC4840067.