Thomas Harris Inge, MD, PhD
Disclosures: Nothing to disclose - 08/09/2021
OMB No. 0925-0046, Biographical Sketch Format Page

 

OMB No. 0925-0001 and 0925-0002 (Rev. 12/2020 Approved Through 02/28/2023)

BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors.
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NAME: Inge, Thomas H.

eRA COMMONS USER NAME (credential, e.g., agency login): THINGE

POSITION TITLE: Professor of Surgery & Pediatrics

EDUCATION/TRAINING

INSTITUTION AND LOCATION

DEGREE

 

Completion Date

 

FIELD OF STUDY

 

College of William and Mary, Williamsburg, VA

Medical College of Virginia, Richmond, VA

Stanford University Medical Center, Stanford, CA The Children’s Hospital of Alabama, Birmingham, AL

BS

MD/PhD

05/1987

05/1993

06/1998

06/2000

Biology

Medicine/Immunology

Surgery Residency Pediatric Surgery Fellowship

 

A.              Personal Statement

Early in my academic surgical career, I led a national consensus around medically-appropriate use of surgical therapy for a new and relatively untreated serious health condition:  adolescent severe obesity.  Throughout my professional career, I have dedicated my time to understanding the outcomes of surgery and have shared our findings in the dozens of high-quality manuscripts.  Linking practice to organized clinical research objectives, our team began to critically evaluate surgical interventions and fill gaps in our knowledge base with R03 funding examining beta cell function and insulin resistance in adolescents undergoing gastric bypass beginning in 2005.  However, the major platform for this scholarly work has been U01 funding that was awarded by NIDDK in 2006 to establish the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) research consortium.  I have served as the PI for the Teen-LABS grant through 3 cycles of funding since 2006With the largest and most comprehensive prospective adolescent bariatric study to date, Teen-LABS investigators have analyzed the baseline phenotype and outcomes of 242 individuals who were exposed to bariatric surgery in adolescence.  The cohort has been carefully characterized, including comorbidity burden, cardiometabolic assessments, diabetes, kidney function, fatty liver disease, musculoskeletal pain and disability, weight related quality of life, depressive symptoms, and micronutrient deficiencies.  In my role as PI of Teen LABS, and surgical director of the Bariatric Center at Children’s Colorado, I will provide scientific leadership for this study and also enthusiastically recruit participants.  

Ongoing projects that I would like to highlight include:

UM1 DK072493                                            

Inge (PI)                                           

09/23/2011 08/31/2021

Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS renewal)

 

1R01DK119450-01A1                                          

Helmrath (PI); Role: Co-PI

09/12/2019-08/31/2024

Surgical or Medical Treatment for Pediatric Type 2 Diabetes (ST2OMP)

 

Citations:

  1. Inge TH, Prigeon R, Elder DA, Jenkins TM, Xanthakos SA, Benoit S, Dolan LM, D’Alessio DA. Gastric bypass improves insulin sensitivity and β-cell function in severely obese adolescents. J Pediatr. 2015 PMID: 26363548.
  2. Inge T, Krebs N, Garcia V, Skelton J, et.al. Bariatric Surgery for Severely Overweight Adolescents: Concerns and Recommendations. Pediatrics, 2004; 114: 217-223. PMID: 15231931
  3. Inge TH, Zeller M, Harmon C, Helmrath M, et.al. Teen-Longitudinal Assessment of Bariatric Surgery: methodological features of the first prospective multicenter study of adolescent bariatric surgery. Journal of Pediatric Surgery. 2007 Nov;42(11):1969-71. PMCID: PMC2293292
  4. Ryder JR, Edwards NM, Gupta R, Khoury J, et.al. Changes in Functional Mobility and Musculoskeletal Pain After Bariatric Surgery in Teens wWith Severe Obesity: Teen-Longitudinal Assessment of Bariatric Surgery (LABS) Study. JAMA Pediatr. 2016 Sep 1;170(9):871-7.
  5. Inge TH, Laffel LM, Jenkins TM, Marcus MD, et.al. Teen–Longitudinal Assessment of Bariatric Surgery (Teen-LABS) and Treatment Options of Type 2 Diabetes in Adolescents and Youth (TODAY) Consortia. Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents. JAMA Pediatr. 2018 May 1;172(5):452-460.
  6. Inge TH, Zeller MH, Jenkins TM, Helmrath M, et.al. Perioperative Outcomes of Adolescents Undergoing Bariatric Surgery: The Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study. JAMA Pediatr. 2014 Jan;168(1):47-53. PMCID: PMC4060250
  7. Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, et.al.  Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents. N Engl J Med. 2016 Jan 14;374(2):113-23
  8. Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, et.al. Teen–LABS Consortium. Five-Year Outcomes of Gastric Bypass in Adolescents as Compared with Adults. N Engl J Med. 2019 May 30;380(22):2136-2145.

 

B.              Positions, Scientific Appointments, and Honors

 

Positions and Scientific Appointments

19931998                            General Surgery Residency, Stanford University Medical Center, Palo Alto, CA

19982000                            Pediatric Surgery Fellowship, The Children’s Hospital of Alabama, Birmingham, AL

20002006                            Assistant Professor of Surgery & Pediatrics, University of Cincinnati, Cincinnati, OH

2001Present              Fellow, American College of Surgeons (FACS)

2002Present              Fellow, American Academy of Pediatrics (FAAP)

2003 – Present              Member, American Society for Metabolic and Bariatric Surgery (ASMBS)

2004 – Present              Member, The Obesity Society

2005 – Present              Member, FDA/CDRH Gastroenterology & Urology Devices Panel

20062011                            Associate Professor of Surgery & Pediatrics, University of Cincinnati, Cincinnati, OH

2006 – Present              Member, Society for University Surgeons

20112017                    Professor of Surgery & Pediatrics (with tenure), University of Cincinnati, Cincinnati, OH

2017 – Present              Professor and Division Chief of Pediatric Surgery, University of Colorado & Children’s Hospital Colorado, Aurora, CO

2018 – Present              Member, American Surgical Association

 

Honors 

2004                                                        Invited Speaker, NIDDK, Clinical Obesity Research Panel Meeting; Bethesda, MD

2006                                                        Invited Speaker, NIDDK, Clinical Obesity Research Panel Meeting; Bethesda, MD

2010                                                        Invited Speaker, NIDDK Endocrinology Division Grand Rounds; Bethesda, MD

2010                                                        Invited Plenary Speaker, NIH Obesity Research Task Force Seminar on Bariatric Surgery;

Bethesda, MD

2013              Invited Presenter, Long Term Outcomes of Bariatric Surgery workshop at Lister Hill Center Auditorium, National Library of Medicine, National Institutes of Health; Bethesda, MD

2015              Invited International Distinguished Faculty/Presenter, 3rd World Congress on Interventional Therapies for Type 2 Diabetes; London, England

2017              Invited Speaker, NIDDK Workshop, Developing Precision Medicine Approaches to the Treatment of Severe Obesity in Adolescents; Rockville, MD

 

C.              Contributions to Science

1.   Early in my career as a clinical investigator, my publications highlighted the need for an organized and conservative clinical approach to the evaluation and surgical management of adolescents who were developing health problems associated with severe obesity. In addition to providing clinical guidelines, these publications also identified and described clinical challenges and knowledge gaps in the field.

a.   Inge TH, Zeller M, Lawson L, Daniels SR. Critical Appraisal of the Evidence Supporting Bariatric Surgery for Weight Management in Adolescence. Journal of Pediatrics. 2005 Jul;147(1):10-9. PMID: 16027686

  1. Inge TH, Donnelly LF, Vierra M, Cohen A, Daniels SR, Garcia VF. Managing Bariatric Patients In a Childrens Hospital: Radiologic Considerations and Limitations. Journal of Pediatric Surgery, 2005. 40:609-617. PMID: 15852267

 

  1. By first developing an appropriate clinical framework for patient evaluation and selection for surgery, the next step scientifically was to begin to study this very unique group of young patients who were developing a significant burden of obesity related health problems. In addition, our group was one of the first to begin to examine a wide range of clinical outcomes of surgical treatment at our center.

a.      Kalra M, Inge T, Garcia V, Daniels S, Lawson L, Curti R, Cohen A, Amin R. Obstructive Sleep Apnea in Extremely Overweight Adolescents Undergoing Bariatric Surgery. Obesity Research 2005 13:1175-1179. PMID: 16076986

b.      Xanthakos S, Miles L, Bucuvalas J, Daniels S, Garcia V, Inge T. Histologic Spectrum of Nonalcoholic Fatty Liver Disease in Morbidly Obese Adolescents. Clinical Gastroenterology and Hepatology, 2006 Feb;4(2):226-32. PMID: 16469684

c.      Ippisch HM, Inge TH, Daniels SR, Wang B, Khoury PR, Witt SA, Glascock BJ, Garcia VF, Kimball TR. Reversibility of Cardiac Abnormalities in Morbidly Obese Adolescents. Journal of the American College of Cardiology 2008 Apr 8;51(14):1342-8. PMID: 18387434

d.      Inge TH, Miyano G, Bean J, Helmrath M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt ML, Dolan LM. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics. 2009 Jan;123(1):214-22. PMID: 19117885

 

  1. In an effort to model the long term effects of untreated childhood obesity, we next examined the effect of a history of adolescent obesity on adult health status, testing the hypothesis that adolescent obesity would be associated with greater risks of adverse health later in life. Indeed we found that compared with healthy weight at age 18, class 2 obesity at age 18 independently and significantly increased the risk of a number of comorbid conditions in severely obese adults.

a.      Jenkins TM, Buncher CR, Akers R, Daniels SR, Lawson ML, Khoury PR, Wilson TP, Inge TH. Validation of a weight history questionnaire to identify adolescent obesity. Obes Surg. 2013 Sep;23(9):1404-12. PMID: 23475789

b.      Inge TH, King WC, Jenkins TM, Courcoulas AP, Mitsnefes M, Flum DR, Wolfe BM, Pomp A, Dakin GF, Khandelwal S, Zeller MH, Horlick M, Pender JR, Chen JY, Daniels SR. The effect of obesity in adolescence on adult health status. Pediatrics. 2013 Dec;132(6):1098-104. PMCID: PMC3838536

 

 

Complete List of Published Work in MyBibliography http://www.ncbi.nlm.nih.gov/sites/myncbi/thomas.inge.1/bibliography/44514279/public/?sort=date&direction=ascending