Argye Hillis-Trupe, MD, MA
Disclosures: Nothing to disclose - 04/09/2021
OMB No. 0925-0046, Biographical Sketch Format Page

OMB No. 0925-0001 and 0925-0002 (Rev. 03/2020 Approved Through 02/28/2023)

BIOGRAPHICAL SKETCH

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NAME: Argye E. Hillis

eRA COMMONS USER NAME (credential, e.g., agency login): AHILLIS

POSITION TITLE: Professor of Neurology, Cognitive Science, and Physical Medicine & Rehabilitation

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

 

Completion Date

MM/YYYY

 

FIELD OF STUDY

 

George Washington University, Washington, DC

BA

05/1980

Speech Language Pathology/Audiology

George Washington University, Washington, DC

MA

05/1981

Speech Language Pathology

Johns Hopkins Univ. School of Medicine, Baltimore, MD

        MD

06/1995

Medicine

  1. Personal Statement

I am a vascular and cognitive neurologist with an extensive experience in clinical research and management of patients with neurocognitive disorders, with additional research training and experience in the fields of cognitive neuroscience and speech-language pathology prior to medical school. I am currently a Professor at the Department of Neurology, with joint appointments in Cognitive Science and Physical Medicine & Rehabilitation. I serve as a Deputy Director of the Neurology Department. My laboratory lab focuses on assessment and treatment of post-stroke aphasia and primary progressive aphasia, and identifying mechanisms of recovery of cognitive deficits after acute ischemic stroke. I have had continuous NIH funding for this research since the beginning of my K award, which started immediately after completion of my residency. I direct the mentorship and career development programs in the department, and served as the Residency Program Director for nearly a decade. Serving as the PI of the NINDS Research Education program (R25) awarded to Johns Hopkins has been exceptionally gratifying.  I have also served as the Senior Mentor for several previous R25 awardees.  One of my greatest passions is guiding the career development of young scientists in neurology, and I have especially found it rewarding to mentor clinician-scientists to become independent investigators. I have served as mentor for 5 K23 or K99 awardees and 1 AHA career development awardee, who are all independent scientists in academic positions; 1 is now a Professor; 3 are Associate Professors.  I am strongly committed to overseeing the research education of clinician-scientists and to improving diversity among clinician-scientists in Neurology. 

 

Ongoing grants that I would like to highlight include:

 

1.              NIDCD P50 DC014664 (PI: J. Fridriksson) “Center for the Study of Aphasia Recovery (C-STAR)”             

4/1/2016 – 3/30/25    Role: PI of Project 2, PI of Clinical Core.

2.              NIDCD R01 DC05375 (PI: AE Hillis), “Neural Basis for Language Deficits in Acute Stroke & Recovery”  7/1/2002 – 2/28/23    Role: PI

3.              NIDCD R01 DC015466 – (PI: Hillis) Recovery of Affective Prosody after Stroke08/01/17 – 07/30/22 Role: PI

4. R01 DC011317 (PI: Meyer) Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia

08/01/2011-07/31/2022Role: Site PI

 

Citations:

 

A1. Gottesman RF & Hillis AE. Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke. Lancet Neurology 2010; 9: 895-905. PMCID: PMC3592203A2.

A2. Newhart M, Trupe LA, Gomez Y, Cloutman L, Molitoris JJ, Davis C, Leigh R, Gottesman RF, Race D, Hillis AE. Asyntactic comprehension, working memory, and acute ischemia in Broca’s area versus angular gyrus. Cortex. 2012;48(10):1288-97. PMCID:PMC3389171

A3. Wright A,               Tippett D, Saxena S, Sebastian R, Breining B, Faria A, Hillis AE. Leukoaraiosis is independently associated with naming outcome in poststroke aphasia.  Neurology. 2018 Aug 7;91(6):e526-e532. PMCID: PMC6105047

A4. Keser Z, Sebastian R, Hasan KM, Hillis AE. (2020) Right hemispheric homologous language pathways negatively predicts poststroke naming recovery. Stroke, 51(3), 1002-1005.

 

B. Positions and Scientific Appointments (in reverse chronological order)

09/20-present              National Deafness and Communication Disorders (NIDCD) Advisory Council

04/20-present              Deputy Editor, Stroke

04/19-04/20              Reviewing Editor, E-Life

08/18-present              Board of Directors, World Stroke Organization

07/18-present              Director, Center for Excellence in Stroke Detection and Treatment, Sheikh Kalifa Stroke Institute

11/14-present              Associate Editor, Practice Update, Neurology

04/14-03/20              Associate Editor, Stroke

11/12-11/17              Board of Directors, American Neurological Association

06/09-12/12              Advisory Board, Nature Clinical Practice Neurology (renamed Nature Reviews Neurology)

01/08-present              Deputy Director (Executive Vice Chair) Department of Neurology, Johns Hopkins Medicine

01/08-12/13              Associate Editor, Brain

01/08-present              Associate Editor, Aphasiology

03/07-02/09              Co-Editor, Neurocase

06/06-present               Professor of Neurology, Johns Hopkins University School of Medicine; joint appointments in Physical Medicine & Rehabilitation and in Cognitive Science (JHU)

06/06-present              Director of the Cerebrovascular Division, Department of Neurology, Johns Hopkins Medicine

10/03-6/06              Associate Professor of Neurology, Johns Hopkins University School of Medicine; joint appointments in Physical Medicine & Rehabilitation and in Cognitive Science (JHU)

05/04-05/13              Co-Editor in Chief, Behavioural Neurology

01/04-01/06               Associate Editor, American Journal of Speech Language Pathology

06/02-6/05                            Associate Editor, Annals of Neurology

06/00-05/06              Associate Editor, Language and Cognitive Processes

07/99-10/03               Assistant Professor, Department of Neurology, Johns Hopkins University School of Medicine; joint appointment in Cognitive Science, Johns Hopkins University

01/97-12/06              Action Editor, Cognitive Neuropsychology.

06/96-6/99                            Resident in Neurology; Johns Hopkins Hospital; Baltimore, MD.

06/95-6/96               Resident (PGY 1) in Internal Medicine; Greater Baltimore Medical Center; Baltimore, MD. 

12/91-6/95                Associate Research Scientist, Johns Hopkins University, Department of Cognitive Science

08/89-8/91                            Director, Neurological Rehabilitation; Medical Rehabilitation Center of Maryland; Balto, MD.

01/88-5/88                  Instructor, Speech-Language Pathology; Loyola College of Maryland; Baltimore, MD.

03/85-8/89                Director, Speech-Language Pathology; Medical Rehabilitation Center of MD; Baltimore, MD.

06/82-3/85                  Speech-Language Pathologist; Good Samaritan Hospital; Baltimore, MD.

HONORS:             

Alpha Omega Alpha;

Phi Beta Kappa;

Intern of the Year;

HealthSouth Special Achievement Award for Outstanding Clinical Services;

National Stroke Association Research Fellow             

Derek Denny-Brown Neurological Scholar Award (from the American Neurological Association), 2003

Norman Geschwind Award in Behavioral Neurology (from the American Academy of Neurology), 2004

The Justine and Yves Sergent Award in Cognitive Neuroscience, 2007

Osler Housestaff Teaching Award, 2007

Fellow of the American Heart Association

Fellow of the American Neurological Association

Fellow of the World Stroke Organization & Board of Directors

 

Center for Scientific Review:

Special Emphasis Panel, ZRG1 BBBP - December, 2000

Special Emphasis Panel, ZDC1 SRB - November, 2001

Study Section,              Biobehavioral and Behavioral Processes 3- 2002

Study Section, Language and Communication  (2003-2007) (standing member)

Special Emphasis Panel, ZAG1 SRC(99)- June, 2003

Study Section, Language and Communication, June 5-6, 2009

Special Emphasis Panel, ZAG1 ZIJ4 04, Proteinopathies in ALS-Dementia – June 29, 2009

NIH/F12A, Cognition, Language, and Perception Fellowship Panel March 5-6, 2010

ZNS1 SRB-S (20) Resident Research RFA – December 11, 2009

NIH/F12A, Cognition, Language, and Perception Fellowship Panel, November 13, 2009

Study Section, ANIE (Acute Neural Injury and Epilepsy), June, 5-6, 2010

Special Emphasis Panel, BBBP-D0385, July 14, 2010

Study Section, ANIE (Acute Neural Injury and Epilepsy), June, 11-12, 2011

Special Emphasis Panel ZRG1 DTCSA, June 27, 2012

Study Section, ANIE (Acute Neural Injury and Epilepsy), Oct 25-26, 2012

Special Emphasis Panel ZDC1 SRB-R, April 4, 2013

Special Emphasis Panel ZDC1 SRB-Y, June 19, 2013

Communication Disorders Review Committee (CDRC) (2014-2019) (standing member)

Special Emphasis Panel ZNS1 SRB-G, November 8, 2016

ZNS1 SRB-O (14) NINDS Loan Repayment Program Review, 2021

 

  1. Contribution to Science
  1. Uncovering the cognitive mechanisms underlying naming, reading, and spelling – Most of my early publications focused on providing evidence for particular components of cognitive architectures of language tasks, based on detailed analysis of impaired patterns of performance on language by individuals with focal lesions (mostly chronic stroke).  By manipulating tasks and language stimuli in various experiments, and analyzing the influence of these manipulations on accuracy and the types of errors made, I was able to draw inferences about selective cognitive mechanisms that were impaired or spared in individual patients. I gained expertise in this type of analysis- the domain of cognitive neuropsychology- through collaborations with the Cognitive Science Department at Johns Hopkins University. We have had an impact on the field by characterizing many of the cognitive mechanisms and spatial representations underlying naming, reading, and spelling. I have had a lead role in many of these studies.

C1. Caramazza, A. & Hillis, A.E. (1990). Spatial representation of words in the brain implied by studies of a unilateral neglect patient. Nature, 346, 267-269. 

C2. Caramazza, A. & Hillis, A.E. (1991).  Lexical organization of nouns and verbs in the brain.  Nature, 349, 788-790.

C3. Hillis, A.E. & Caramazza, A. (1991). Category-specific naming and comprehension impairment: A double dissociation.  Brain, 114, 2081-2094.

C.4. Hillis, A.E., Boatman, D., Hart, J. & Gordon, B. (1999).  Making sense out of jargon: a

neurolinguistic and computational account of jargon aphasia.  Neurology, 53, 1813-1824

 

  1. Using cognitive models of language processes to guide rehabilitation of aphasia – I was a leading investigator in the field of aphasia in showing how a cognitive model of the language task to be treated, and detailed analysis of the cognitive processes that were impaired in an individual patient, might guide one’s rehabilitation or expectations from rehabilitation.  This research had an impact on the field of speech-language pathology (in which I was working at the time), as well my current research in rehabilitation of aphasia, combining neuromodulation with language rehabilitation. I directed this research, mentoring numerous speech-language pathologists and other trainees over the decades. This line of investigation eventually led to an edited book, The Handbook of Adult Language Disorders, which integrates a model of the cognitive processes underlying each language domain (e.g. reading) and a model of the neural mechanisms underlying the same domain, with the treatment of the same language domain. The second edition was published in 2015.

C5. Hillis, A.E. (1989).  Efficacy and generalization of treatment for aphasic naming errors.  Archives of Physical Medicine and Rehabilitation, 70, 632-636.

C6. Hillis, A.E. (1993).  The role of models of language processing in rehabilitation of language impairments.  Aphasiology, 7, 5-26.

C6. Hillis, A.E. (1998).  Treatment of naming disorders: new issues regarding old therapies.  Journal of the International Neuropsychological Society, 4, 648-660.

C8. Sebastian, R., Saxena, S., Tsapkini, K., Faria, A.V., Long, C., Wright, A., Davis, C., Tippett, D.C., Mourdoukoutas, A.P., Bikson, M., Celnik, P., & Hillis, A.E. (2016). Cerebellar tDCS: A novel approach to augment language treatment post stroke. Frontiers in Human Neuroscience, 10, 695. PMC5226957

 

  1. Identifying the areas of dysfunctional brain tissue responsible for language deficits in acute stroke – Throughout medical school and residency I continued my research on aphasia. About the time I was completing residency, new magnetic resonance (MR) imaging of acute stroke was developed that could, for the first time, show areas of acute infarction and areas of hypoperfusion that were responsible for many of the language deficits in the first few hours of stroke.  Many chronic stroke patients I had studied had very large lesions and had recovered all but minor selective deficits in language. But it was impossible to determine what parts of the lesions were responsible for the deficits that failed to recover.  I started to study, on large scale, patients at the onset of stroke, before the opportunity for recovery or reorganization of structure-function relationships, identifying areas of ischemia and hypoperfusion (on MR diffusion and perfusion weighted imaging) associated with their deficits. Furthermore, I obtained additional evidence that particular areas were critical for a function by showing that restoring blood flow to a hypoperfused area could result in recovery of the associated language function.  I relied on this novel methodology for identifying areas critical to a number of cognitive processes underlying language (supported by a K23 and an R01 that has been renewed twice). I have consulted with other neurologists and cognitive scientists worldwide to assist or mentor them in using this approach to identifying areas of brain critical for specific functions, before the opportunity for recovery or reorganization.

C9. Hillis, A.E., Wityk, R., Barker, P.B., Caramazza, A. (2003). Neural regions essential for writing verbs.  Nature Neuroscience, 6, 19-20.

C10. Hillis, A.E., Kleinman, K.T., Newhart, M., Heidler-Gary, J., Gottesman, R., Barker, P.B., Aldrich, E, Llinas, R., Wityk, R., Chaudhry, P.  (2006). Restoring cerebral blood flow reveals neural regions critical for naming. Journal of Neuroscience, 26, 8069-8073.

C11. DeLeon, J., Gottesman, R.F., Kleinman, J.T., Newhart, M., Davis, C., Heidler-Gary, J., Lee, A., Hillis, A.E. (2007) Neural regions essential for distinct cognitive processes underlying picture naming. Brain, 130, 1408-22.

C12. Cloutman, L., Gingis, L., Newhart, M., Davis, C., Heidler-Gary, J., Crinion, J., Hillis, A.E. (2009). A neural network critical for spelling. Annals of Neurology. 66, 249-53. PMCID: PMC2745512

 

C4. Identifying the underlying causes of Primary Progressive Aphasia and novel methods to improve communication or reduce the rate of decline. 

My long interest in aphasia led me to investigate the clinical syndrome of primary progressive aphasia, and what this clinical syndrome reveals about how language is organized in the brain.  My outpatient clinic currently focuses on management of primary progressive aphasia, and I follow one of the largest cohorts of this condition in the country.  We have carried out longitudinal functional and structural imaging studies and novel treatment studies in this unique population, and we are just beginning to carry out genetic studies in PPA and other neurodegenerative diseases. 

 

C.13. Hillis, A. E., Oh, S., & Ken, L. (2004). Deterioration of naming nouns versus verbs in primary progressive aphasia. Annals of Neurology, 55(2), 268-275.

C.14. Sepelyak K, Crinion J, Molitoris J, Epstein-Peterson Z, Bann M, Davis C, Newhart M, Heidler-Gary Tsapkini K, Hillis AE.  Patterns of breakdown in spelling in primary progressive aphasia. Cortex 2011 PMCID: PMC2889229

C. 15. Tsapkini, K., Frangakis, C., Gomez, Y., Davis, C., & Hillis, A. E. (2014). Augmentation of spelling therapy with transcranial direct current stimulation in primary progressive aphasia: preliminary results and challenges. Aphasiology, 28(8-9), 1112-1130.

C.16. Tsapkini, K., Webster, K. T., Ficek, B. N., Desmond, J. E., Onyike, C. U., Rapp, B., ... & Hillis, A. E. (2018). Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 4, 461-472.

 

 

C5.              Identifying mechanisms of recovery of language and cognitive deficits after stroke – My most recent work has relied on longitudinal functional and structural imaging and cognitive assessments after acute stroke and over the first year of recovery to identify the mechanisms of recovery of language and other cognitive processes.  We have been obtaining task-related and task-free (resting state) fMRI studies, perfusion, DTI, and other structural scans and detailed cognitive testing at 4 time points. While others have reported group patterns (e.g. a shift from mostly right hemisphere activation to mostly perilesional left hemisphere activation during language at the chronic stage), we have discovered marked differences in patterns of recovery across individuals and across language tasks within individuals. We have also demonstrated that different mechanisms of recovery (e.g. restoration of blood flow, recovery from diaschisis, reorganization of structure-function relationships) have distinct time courses. This work has led to some novel interventions to augment specific mechanisms at particular stages post-stroke, such as temporary blood pressure elevation to augment restoration of blood flow in acute stroke (pilot randomized trial), transcranial direct current stimulation with language therapy in the first few months after stroke to augment reorganization of structure-function relationships (ongoing cross-over trial). 

 

C17.  Jarso, S., Li, M., Faria, A., Davis, C., Sebastian, R., Tsapkini, K., Hillis, A.E. (2013) Distinct mechanisms and timing of language recovery after stroke.  Cognitive Neuropsychology. 30:454-75. PMCID: PMC3979443

C18.  Sebastian, R., Long, C., Purcell, J.J., Faria, A.V., Lindquist, M., Jarso, S., Race, D., Davis, C., Posner, J., Wright, A., Hillis, A.E.  Imaging network level language recovery after left PCA stroke.  Restorative Neurology and Neuroscience (2016). 11;34(4):473-89. PMCID: PMC5003759

C19. Purcell, J., Sebastian, R., Jarso, S., Davis C., Posner J., Wright, A., & Hillis, A.E. (2017).  Recovery of orthographic processing after stroke: A longitudinal fMRI study. Cortex, 92, 103-118. PMC5489136

C.20. Hillis, A. E., Beh, Y. Y., Sebastian, R., Breining, B., Tippett, D. C., Wright, A., ... & Fridriksson, J. (2018). Predicting recovery in acute poststroke aphasia. Annals of neurology, 83(3), 612-622.

 

Complete list of published research in: http://www.ncbi.nlm.nih.gov/sites/myncbi/argye.hillis.1/bibliography/41138879/public/?sort=date&direction=descending Note: this link includes papers supported by my grants on which I am not author.