Matthew Ladra, MD
Disclosures: Nothing to disclose - 07/16/2019

Program Director/Principal Investigator (Ladra, Matthew, M):             

BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.

 

NAME

Matthew Ladra

POSITION TITLE

Assistant Professor, Radiation Oncology

Johns Hopkins School of Medicine

Sibley Memorial Hospital Dept of Radiation Oncology

 

eRA COMMONS USER NAME (credential, e.g., agency login)

 

EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

MM/YY

FIELD OF STUDY

 

 

 

 

Princeton University, Princeton NJ

Tulane School of Medicine, New Orleans LA

St. Mary’s Medical Center, San Francisco CA

University of Washington, Seattle WA

Massachusetts General Hospital, Boston MA

 

BA

MD/MPH

Intern

Resident

Fellow

 

6/2000

6/2007

6/2008

6/2012

8/2014

 

Molecular Biology

Medicine

Internal Medicine

Radiation Oncology

Pediatric Proton Therapy

 

 

 

 

 

 

Please refer to the application instructions in order to complete sections A, B, C, and D of the Biographical Sketch.

 

 

  1. Personal Statement

Currently I serve as the director of the pediatric radiation oncology program for the Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital, a clinical collaboration between Children’s National Medical Center and the Johns Hopkins Sidney Kimmel Cancer Center. I am also an assistant professor in the Department of Radiation Oncology and Molecular Radiation Sciences at Johns Hopkins University School of Medicine and adjunct faculty at Children’s National Medical Center in the department of Oncology and Hematology.

 

My research focuses on late effects in pediatric brain tumor and sarcoma patients.  This effort led to the publication of the first prospective trial using proton therapy for the treatment of pediatric rhabdomyosarcoma with the goal of reducing long-term complications of radiation therapy.  Currently my primary research focus has been on neurocognitive impact of CNS radiation in pediatric brain tumor patients.  With the help of Dr. Kristina Hardy, I have reviewed the neurocognitive outcomes for the recently closed Children’s Oncology Group ACNS0331 study of standard risk medulloblastoma and using advanced radiation dosimetry techniques, have correlated neurocognitive outcomes with patterns of radiation dose to sensitive brain structures.  This work has been present as an oral session during both the International Society of Pediatric Neuro-oncology and the Children’s Oncology Group annual meeting, where our project was awarded the young investigator prize for best original research Selected recent publications related to my work are:

 

PUBLICATIONS:

 

Original Research

 

 

  1. Rao AD, Figueiredo ML, Chen Q, Alcorn SR, Chen MJ, Ladra MM, et al. Clinical practice and outcomes of palliative radiation therapy in pediatric oncology patients: an international comparison of experiences from two distinct countries and healthcare systems.  Radiother Oncol. 2019;140:1-5.

 

  1. Rao AD, Lee J, Fu W, Nicholas S, Alcorn SR, Ladra MM, Moore J, et al. Precision of 2 Low-dose Abdomen/Pelvis Cone Beam Computed Tomography Protocols for Alignment to Bone and Soft Tissue in Pediatric Patients Receiving Image Guided Radiation Therapy. Pract Radiat Oncol. 2019.

 

  1. Rao AD, Chen Q, Million L, Spunt SL, Ladra MM, Fitzgerald TJ, Hu C, et al. Preoperative Intensity Modulated Radiation Therapy Compared to Three-Dimensional Conformal Radiation Therapy for High-Grade Extremity Sarcomas in Children: Analysis of the Children's Oncology Group Study ARST0332. Int J Radiat Oncol Biol Phys. 2019;103(1):38-44.

 

  1. Rao AD, Ladra MM, Dunn E, Kumar R, et al. A Road Map for Important Centers of Growth in the Pediatric Skeleton to Consider During Radiation Therapy and Associated Clinical Correlates of Radiation-Induced Growth Toxicity. Int J Radiat Oncol Biol Phys. 2019;103(3):669-79.

 

  1. Alcorn S, Nilsson K, Rao AD, Ladra MM, Ermoian RP, Villar RC, et al. Practice Patterns of Stereotactic Radiotherapy in Pediatrics: Results From an International Pediatric Research Consortium. J Pediatr Hematol Oncol. 2018;40(7):522-6.

 

  1. Rao, A.D., Ladra M.M., Rashid AS, Chen Q, et al., Reirradiation for Recurrent Pediatric Central Nervous System Malignancies: A Multi-institutional Review. Int J Radiat Oncol Biol Phys, 2017. 99(3): p. 634-641.

 

  1. Carson RA, Ladra MM, Choflet A. Development of Pediatric Emergency Protocols and Communication Plans in Pediatric Radiation Oncology: Multidisciplinary Core Competencies. Pediatr Qual Saf. 2017;2(5):e040.

 

  1. Rao AD, Chen Q, Ermoian RP, Alcorn SR, Ladra MM, Figueiredo MLS, Chen MJ, et al. Practice patterns of palliative radiation therapy in pediatric oncology patients in an international pediatric research consortium. Pediatr Blood Cancer. 2017.

 

  1. Shen CJ, Hu C, Ladra MM, Narang AK, Pollack CE, Terezakis SA. Socioeconomic factors affect the selection of proton radiation therapy for children. Cancer. 2017

 

  1. Ladra MM, Mandeville HC, Niemierko A, Padera TP, Friedmann AM, MacDonald SM, Ebb D, Chen YL, Tarbell NJ, Yock TI: Local Failure in Parameningeal Rhabdomyosarcoma Correlates With Poor Response to Induction Chemotherapy. International Journal of Radiation Oncolology Biology & Physics, 2015

 

  1. Lucas JT, Ladra MM, MacDonald SM, Friedmann AM, Busse P, Tarbell NJ, Yock TI: Proton Therapy for Pediatric and Adolescent Esthesioneuroblastoma. Pediatric Blood and Cancer, 2015

 

  1. Ladra MM, Szymonifka JD, Mahajan A, MacDonald SM, Marcus KJ, Friedmann AM, Grosshans D, Tarbell NJ, Yock TI: Preliminary Results of a Phase II Trial of Proton Radiotherapy for Pediatric Rhabdomyosarcoma. Journal of Clinical Oncology 32:3762-70, 2014

 

  1. Ladra MM, Edgington SK, Mahajan A, MacDonald SM, Grosshans D, Tarbell NJ, Yock TI: A Dosimetric Comparison of Proton and Intensity Modulated Radiation Therapy in Pediatric Rhabdomyosarcoma Patients Enrolled on a Prospective Phase II Proton Study. Radiotherapy & Oncology 113:77-83, 2014

 

  1. Ermoian R, Ladra MM, Patel S. Children’s Oncology Group L991 Final Study Report: Establishing an Important Benchmark for Assessing Late Effects of Trimodality Care Of Pediatric Patients Treated for High Grade Gliomas. Translational Pediatrics July 2014

 

  1. Liao JJ, Parvathaneni U, Laramore GE, Ladra MM: Fast Neutron Radiotherapy for Primary Mucosal Melanomas of the Head and Neck. Head & Neck 36:1162-7, 2014

 

Review Articles

 

 

  1. Ladra, M.M., S.M. MacDonald, and S.A. Terezakis, Proton therapy for central nervous system tumors in children. Pediatr Blood Cancer, 2018. 65(7): p. e27046.

 

  1. Ladra, M.M., K.K. Wang, and S.A. Terezakis, Pencil-beam scanning for pediatric rhabdomyosarcoma: Promise and precautions. Pediatr Blood Cancer, 2016. 63(10): p. 1698-9.

 

  1. Ladra MM, Yock TI: Proton radiotherapy for pediatric sarcoma. Cancers 6:112-27, 2014

 

 

Book Chapters

  1. Ladra MM, Terazakis SA, Pediatric Rhabdomyosarcoma. Chapter 3, Thomas Merchant's Pediatric Radiation Oncology Springer 2019
  2. Deville CS, Ladra MM, et al., Sarcoma. Chapter 8 in Nancy Lee’s Target Volume Delineation and Treatment Planning for Particle Therapy. Springer 2018
  3. MacDonald SM, Ladra MM, Tarbell NJ, Pediatric Rhabdomyosarcoma. Chapter 12, Nancy Tarbell’s Pediatric Radiation Oncology Textbook 2017 Edition
  4. Ladra MM, Yock TY, Rhabdomyosarcoma. Chapter 12, Terazakis's Contouring Pediatric Tumors  2018 Edition
  5. Ladra MM, MacDonald SM, Radiation Therapy for Pediatric Brain Tumors. Chapter 10, Amar Gajjar's Pediatric CNS Tumors Springer 2017
  6. Ladra MM, Yock T, Friedmann A.  Adjuvant Therapy for Pediatric Malignancies of the Head and Neck. Chapter 59, Sataloff’s Textbook of Otolaryngology 2015

 

Positions and Employment             

4/2016- Present   Johns Hopkins School Of Medicine                 Washington, DC

Assistant Professor, Radiation Oncology and Molecular Radiation Sciences

8/2014-1/2016    Provision Center for Proton Therapy             Knoxville, Tennessee

Radiation Oncologist. Director, Pediatric Service

 

Journal peer review activities  

International Journal Of Radiation Oncology Biology & Physics (ad hoc reviewer) 2017-present

Pediatric Blood and Cancer (ad hoc reviewer) 2017-present

Radiotherapy and Oncology (ad hoc reviewer) 2018-present

Journal of Neuro-Oncology (Junior Editor) 2019-present

Pediatric Blood and Cancer (Assistant Editor) 2020-present

 

 

Advisory Committees, Review Groups/Study Sections

COG Radiation Oncology PI for Intermediate Risk Rhabdomyosarcoma COG study TBD

COG Radiation PI for ACNS 1422 Study (WNT Medullo Study) 2019-present

COG Renal Tumors Committee Member (2017-Present)

ASTRO Congressional Outreach Subcommittee (2018-Present)

Pediatric Brain Tumor Consortium Radiation Co-Chair (2018-Present)

 

 

 

              Other Experience and Professional Memberships

2012-                      Children’s Oncology Group Member

2004-             American Medical Association

2008-               ASTRO (American Society of Therapeutic Radiation Oncology)

2008-               American College of Radiology and Radiologic Society of North America

 

 

  1. Research Support

 

No current research support

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)              Page 3                Biographical Sketch Format Page