Nauder Faraday, MD, MPH
Disclosures: stock ownership-Amgen|stock ownership-Celgene|stock ownership-Johnson and Johnson|stock ownership-Eli Lilly and Company|stock ownership-Medtronic, Inc.|stock ownership-Novartis AG|stock ownership-NovoNordisk
Curriculum Vitae

                           

CURRICULUM VITAE

 

Nauder Faraday, MD MPH                                                                                                  May 2019

 

Current Appointments

 

              Professor

              Department of Anesthesiology/Critical Care Medicine (ACCM)

              Joint Appointments: Medicine, Surgery, and Epidemiology/Bloomberg School of Public Health

              Vice-Chair, ACCM Faculty and Staff Development

              Director, ACCM Clinical Research

              Sr. Associate Dean for Faculty Development

              Johns Hopkins University School of Medicine

                                                                                                               

Contact Information

 

              Department of Anesthesiology and Critical Care Medicine

              Johns Hopkins Hospital, Meyer 298

              600 North Wolfe Street

              Baltimore, MD 21287

              Voicemail: 410-502-7085; fax: 410-955-8978; email: nfaraday@jhmi.edu

                                                                     

Education

 

9/80 – 5/84                    B.A.              Columbia College, Columbia University, New York, NY

 

8/84 - 5/88              M.D.              Mount Sinai School of Medicine, CUNY, New York, NY

 

6/10- 5/11              MPH              Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

 

Postdoctoral Clinical Training

 

6/88 - 6/89              Internship                           

                                          Hospital of St. Raphael - Yale University, New Haven, CT

                                          Residency Director:  Phillip J. Noto, M.D.

 

7/89 - 6/92              Residency Anesthesiology

                                          The Johns Hopkins Hospital, Baltimore, MD

                                          Department of Anesthesiology/Critical Care Medicine

                                          Residency Director:  Robert L. Stevenson, M.D.

 

4/92-4/93              Chief Resident, Anesthesiology

                                          Johns Hopkins University School of Medicine, Baltimore, MD             

                                          Department of Anesthesiology/Critical Care Medicine

 

7/92 - 6/93              Fellowship Critical Care Medicine

                                          The Johns Hopkins Hospital, Baltimore, MD

                                          Department of Anesthesiology/Critical Care Medicine

                                          Fellowship Director:  Michael J. Breslow, M.D.

 

9/93 – 5/94              Fellowship Cardiovascular Anesthesiology

                                          The Johns Hopkins Hospital, Baltimore, MD

                                          Department of Anesthesiology and Critical Care Medicine

                                          Fellowship Director: Daniel Nyhan, M.D.

 

Postdoctoral Research Training

 

92 – 94                            Research Fellowship

                                          Johns Hopkins University School of Medicine, Baltimore, MD                                         

                                          Department of Anesthesiology and Critical Care Medicine

                                          Research Director:  Brian A. Rosenfeld, M.D.

                                          Subject:  Perioperative alterations in hemostasis

 

93 – 95                            Research Fellowship             

                                          Johns Hopkins University School of Medicine, Baltimore, MD

                                          Department of Medicine- Divisions of Hematology and Cardiology

                                          Research Directors: Paul F. Bray, M.D. and Pascal Goldschmidt-Clermont, MD

                                          Subject: Molecular, biochemical, and cellular biology of platelet function

 

Professional Experience

 

7/93-10/93              Instructor              

                                          Johns Hopkins University School of Medicine, Baltimore, MD

                                          Department of Anesthesiology/Critical Care Medicine

 

11/93-10/01              Assistant Professor

                                          Johns Hopkins University School of Medicine, Baltimore, MD

                                          Department of Anesthesiology/Critical Care Medicine and Surgery

 

1994-2004              Co-Director, Cardiac Surgical Intensive Care Unit

                                          The Johns Hopkins Hospital, Baltimore, MD

 

1996-1999              Co-Director

                                          Perioperative Research Center

                                          Department of Anesthesiology and Critical Care Medicine

                                          Johns Hopkins University School of Medicine, Baltimore, MD

 

1999-                            Director, Perioperative Hemostasis and Thrombosis Research Laboratory

                                          Department of Anesthesiology and Critical Care Medicine

                                          Johns Hopkins University School of Medicine, Baltimore, MD

Aims: Clinical and translational research to identify novel mechanisms and therapies to prevent and treat perioperative thrombotic and bleeding complications

 

2001- 2012              Associate Professor

                                          Johns Hopkins University School of Medicine, Baltimore, MD

                                          Departments of Anesthesiology/Critical Care Medicine and Surgery

 

2005-                            Director, Perioperative Genomic and Translational Research

                                          Department of Anesthesiology and Critical Care Medicine

                                          Johns Hopkins University School of Medicine, Baltimore, MD

Aims: Identify the genetic and protein basis for development of bleeding, thrombotic, and infectious complications of surgery

 

2012-                            Professor

                                          Department of Anesthesiology/Critical Care Medicine

                                          Johns Hopkins University School of Medicine, Baltimore, MD

 

2012-2017              Vice Chair, JHU School of Medicine Associate Professor Promotions Committee

 

 

2014-                            Vice-Chair for Faculty and Staff Development

                                          Department of Anesthesiology/Critical Care Medicine

                                          Johns Hopkins University School of Medicine, Baltimore, MD

 

2015-                            Director, Clinical Research

                                          Department of Anesthesiology/Critical Care Medicine

                                          Johns Hopkins University School of Medicine, Baltimore, MD

 

2015-                            Professor

                                          Department of Epidemiology

                                          Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

 

2017-                            Sr. Associate Dean for Faculty Development

                                          Johns Hopkins University School of Medicine, Baltimore, MD

 

 

 

RESEARCH ACTIVITIES

 

Publications

 

Peer Reviewed Original Science Publications:

 

1.              Geary N, Farhoody N, Gersony A. Food deprivation dissociates pancreatic glucagon's effect on satiety and hepatic glucose production at dark onset.  Physiol Behav. 1987;39:507-511

 

2.              Hinton V, Esguerra M, Farhoody N, Gersony A, Geary N. Epinephrine inhibits feeding nonspecifically in the rat.  Physiol Behav. 1987;40:109-115

 

3.              Keller SE, Schleifer SJ, Liotta AS, Bond RN, Farhoody N, Stein M. Stress-induced alterations of immunity in hypophysectomized rats. Proc Natl Acad Sci. 1988; 85:9297-9301

 

4.              Beckhardt RN, Faraday N, May M, Torres RA, Strauchen JA. Increased incidence of malignant lymphoma in AIDS: A comparison of risk groups and possible etiologic factors. M. Sinai J Med. 1988;55:383-389,

 

  1. Rosenfeld BA, Faraday N, Campbell DA, Dorman T, Clarkson K, Siedler A, Breslow MJ, Bell W. Perioperative platelet reactivity and the effects of clonidine. Anesthesiology. 1993;79:255-261

 

6.              Faraday N, Goldschmidt-Clermont P, Dise K, Bray PF. Quantitation of soluble fibrinogen binding to platelets by fluorescence activated flow cytometry.  J Lab Clin Med 1994;123:728-740

 

7.              Rosenfeld BA, Faraday N, Campbell D, Sakima N, Bell W. Effects of bedrest on circadian changes in hemostasis.  Thrombosis and Hemostasis 1994;72:281-284

 

8.              Rosenfeld BA, Faraday N, Campbell D, Dise K, Bell W, Goldschmidt-Clermont PJ. Hemostatic effects of stress hormone infusion.  Anesthesiology 1994;81:1116-1126 .

 

9.              Addo JB, Bray PF, Grigoryev D, Faraday N, Goldschmidt-Clermont PJ.  Surface recruitment but not activation of integrin aIIbb3 (GPIIb-IIIa) requires a functional actin cytoskeleton.  Arterioscler, Thromb, Vasc Biol 1995;15:1446-1473

 

10.              Rosenfeld BA, Herfel B, Faraday N, Fuller A, Braine H.  Effects of storage time on quantitative and qualitative platelet function after transfusion.  Anesthesiology 1995;83:1167-72

 

11.              Faraday N, Goldschmidt-Clermont P, Bray PF.  Gender differences in platelet GPIIb-IIIa activation.  Thrombosis and Haemostasis 1997;77: 748-54

 

12.              Rosenfeld BA, Nguyen N-D, Sung I, Faraday N. Neuroendocrine stress hormones do not recreate the postoperative hypercoagulable state. Anesth Analg 1998;86: 640-5

 

13.              Faraday N, Rosenfeld BA.  In vitro hypothermia enhances platelet GPIIb-IIIa activation and P-selectin expression.  Anesthesiology 1998;88: 1579-85

 

14.              Faraday N, Rade JJ, Johns CD, Khetawat G, Noga SJ, DiPersio JF, Jin Y, Nichol JL, Haug JS, Bray PF.  Ex vivo cultured megakaryocytes express functional GPIIb-IIIa receptors and are capable of adenovirus-mediated transgene expression.  Blood 1999;94: 4084-92

 

  1. Khetawat G, Faraday N, Nealen ML, Vijayan KV, Bolton E, Noga SJ, Bray PF.  Human megakaryocytes and platelets contain the estrogen receptor beta and androgen receptor (AR): testosterone regulates AR expression.  Blood 2000;95: 2289-96

 

  1. Faraday N, Scharpf RB, Dodd-o JM, Martinez EA, Rosenfeld BA, Dorman T. Leukocytes can enhance platelet-mediated aggregation and thromboxane release via interaction of PSGL1 with P-selectin.  Anesthesiology 2001;94:145-51

 

  1. Faraday N, Guallar E, Sera VA, Bolton ED, Scharpf RB, Cartarius AM, Emery K, Concord J, Kickler TS. Utility of whole blood hemostatometry using the clot signature analyzer (CSA) for assessment of hemostasis in cardiac surgery. Anesthesiology 2002;96: 1115-22

 

  1. Kim LJ, Martinez EA, Faraday N, Dorman T, Fleisher LA, Perler BA, Williams GM, Chan D, Pronovost PJ. Cardiac troponin I predicts short-term mortality in vascular surgery patients. Circulation 2002;106: 2366-71

 

  1. Dodd-o JM, Hristopoulos ML, Faraday N, Pearse DB. Effect of ischemia reperfusion without airway occlusion on vascular barrier function in the in vivo mouse lung. J Appl Physiol 2003;95: 1971-8

 

  1. Martinez EA, Kim LJ, Faraday N, Rosenfeld BA, Bass EB, Perler BA, Williams GM, Dorman T, Pronovost PJ. Sensitivity of routine intensive care unit surveillance for detecting myocardial ischemia. Crit Care Med 2003;31: 2302-8

 

  1. Faraday N, Braunstein JB, Heldman AW, Bolton ED, Chiles, KA, Gerstenblith G, Schulman SP. Prospective evaluation of the relationship between platelet-leukocyte conjugate formation and recurrent myocardial ischemia in patients with acute coronary syndromes. Platelets 2004;15: 9-14

 

  1. Faraday N, Martinez EA, Scharpf RB, Kasch-Semenza L, Dorman T, Pronovost PJ, Perler B, Gerstenblith G, Bray PF, Fleisher LA. Platelet gene polymorphisms and cardiac risk assessment in vascular surgical patients. Anesthesiology 2004;101: 1291-7

 

  1. Morrell C, Matsushita K, Chiles K, Scharpf R, Yamakuchi M, Simmons A, Mankowski JL, Baldwin W, Faraday N, Lowenstein CJ. Regulation of platelet granule exocytosis by S-nitrosylation. Proc Natl Acad Sci USA 2005;102:3782-7

 

  1. Njoku, DB, Mellerson JL, Taylor MV, Kerr DR, Faraday N, Outschoorn I, Rose NR. Role of CYP2E1 immunoglobulin G4 subclass antibodies and complement in pathogenesis of idiosyncratic drug-induced hepatitis. Clin Vacc Immunol 2006;13: 258-65

 

  1. Becker DM, Segal J, Vaidya D, Yanek LR, Herrera-Galeano JE, Bray PF, Moy TF, Becker LC, Faraday N. Sex differences in platelet reactivity and response to low-dose aspirin therapy. JAMA 295: 1420-27, 2006.

 

  1. Ferlito M, Irani K, Faraday N, Lowenstein CJ. Nitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cells. Proc Natl Acad Sci USA 2006;103:11689-94

 

  1. Faraday N, Becker DM, Yanek YR, Herrera-Galeano JE, Segal JB, Moy TF, Bray PF, Becker LC. Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population. Am J Cardiol 2006;98: 774-9

 

  1. Faraday N, Yanek LR, Mathias R, Herrera-Galeano JE, Vaidya D, Moy TF, Fallin MD, Wilson AF, Bray PF, Becker LC, Becker DM. Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1. Circulation 2007;May 15;115(19):2490-6

 

  1. Bray PF, Mathias RA, Faraday N, Yanek LR, Fallin MD, Herrera-Galeano JE, Wilson AF, Becker LC, Becker DM. Heritability of platelet function in families with premature coronary artery disease. J Thromb Haemost 2007;5:1617-23

 

  1. Bordeaux B, Yanek LR, May TF, White LW, Becker LC, Faraday N, Becker DM. Casual chocolate consumption and inhibition of platelet function. Prev Cardiol 2007;10(4): 175-80

 

  1. Morrell CN, Sun H, Ikeda M, Beique JC, Swaim AM, Mason E, Martin TV, Thompson LE, Gozen O, Ampagoomian D, Sprengel R, Rothestein J, Faraday N, Huganir R, Lowenstein CJ. Glutamate mediates platelet activation through the AMPA receptor. J Exp Med 2008;205(3):575-84

 

  1. Qayyum R, Becker DM, Yanek LR, Moy TF, Becker LC, Faraday N, Vaidya D. Platelet Inhibition by Aspirin 81 and 325 mg/day in Men Versus Women Without Clinically Apparent Cardiovascular Disease. Am J Cardiol 2008;101:1356-63

 

  1. Herrera-Galeano JE, Becker DM, Wilson AF, Yanek LR, Bray P, Vaidya D, Faraday N, Becker LC. A Novel Variant in the Platelet Endothelial Aggregation Receptor-1 Gene Is Associated With Increased Platelet Aggregability. Arterioscler Thromb Vasc Biol 2008;28(8):1484-90

 

  1. Blasco-Colmenares E, Perl TM, Guallar E, Baumgartner WA, Conte JV, Alejo D, Pastor-Barriuso R, Sharrett AR, Faraday N. Aspirin plus clopidogrel and risk of infection after coronary artery bypass surgery. Arch Intern Med. 2009;169: 788-96

 

  1. Faraday N, Yanek LR, Vaidya D, Kral B, Qayyum R, Herrera-Galeano JE, Moy TF, Becker DM, Becker LC. Leukocyte Count is Associated with Increased Platelet Reactivity and Diminished Response to Aspirin in Healthy Individuals with a Family History of Coronary Artery Disease. Thromb Res. 2009;124: 311–317

 

  1. Vaidya D, Yanek LR, Faraday N, Moy TF, Becker LC, Becker DM. Native Platelet Aggregation and Response to Aspirin in Persons with the Metabolic Syndrome and its Components. Metab Syndr Relat Disord. 2009;7(4):289-96

 

  1. Sun H, Swaim A, Herrera JE, Becker D, Becker L, Srivastava K, Thompson LE, Shero MR, Perez-Tamayo A, Suktitpat B, Mathias R, Contractor A, Faraday N, Morrell CN. Platelet Kainate Receptor Signaling Promotes Thrombosis by Stimulating Cyclooxygenase Activation. Circ Res. 2009;105(6):595-603

 

  1. Shuldiner AR, O’Connell JR, Bliden KP, Gandhi A, Ryan K, Horenstein RB, Damcott CM, Pakyz R, Tantry US, Gibson Q, Pollin TI, Post W, Parsa A, Mitchell BD, Faraday N, Herzog W, Gurbel PA. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA. 2009;302(8):849-858

 

  1. Bordeaux BC, Qayyum R, Yanek LR, Vaidya D, Becker LC, Faraday N, Becker DM. Effect of obesity on platelet reactivity and response to low-dose aspirin. Prev Cardiol. 2010; 13(2):56-62

 

  1. Johnson AD, Yanek LR, Chen MH, Faraday N, Larson MG, Tofler G, Lin SJ, Kraja AT, Province MA, Yang Q, Becker DM, O'Donnell CJ, Becker LC. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet 2010;42(7):608-13

 

  1. Mathias RA, Kim Y, Sung H, Yanek LR, Mantese VJ, Hererra-Galeano JE, Ruczinski I, Wilson AF, Faraday N, Becker LC, Becker DM. A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease. BMC Med Genomics 2010;3:22

 

  1. Musunuru K, Post WS, Herzog W, Shen H, O'Connell JR, McArdle PF, Ryan KA, Gibson Q, Cheng YC, Clearfield E, Johnson AD, Tofler G, Yang Q, O'Donnell CJ, Becker DM, Yanek LR, Becker LC, Faraday N, Bielak LF, Peyser PA, Shuldiner AR, Mitchell BD. Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease. Circ Cardiovasc Genet 2010;3:445-53

 

  1. Assimes TL, Hólm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, Erdmann J, Willenborg C, Vaidya D, Xie C, Patterson CC, Morgan TM, Burnett MS, Li M, Hlatky MA, Knowles JW, Thompson JR, Absher D, Iribarren C, Go A, Fortmann SP, Sidney S, Risch N, Tang H, Myers RM, Berger K, Stoll M, Shah SH, Thorgeirsson G, Andersen K, Havulinna AS, Herrera JE, Faraday N, Kim Y, Kral BG, Mathias RA, Ruczinski I, Suktitipat B, Wilson AF, Yanek LR, Becker LC, Linsel-Nitschke P, Lieb W, König IR, Hengstenberg C, Fischer M, Stark K, Reinhard W, Winogradow J, Grassl M, Grosshennig A, Preuss M, Schreiber S, Wichmann HE, Meisinger C, Yee J, Friedlander Y, Do R, Meigs JB, Williams G, Nathan DM, MacRae CA, Qu L, Wilensky RL, Matthai WH Jr, Qasim AN, Hakonarson H, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser VE, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Martinelli N, Olivieri O, Trabetti E, Malerba G, Pignatti PF, Guiducci C, Mirel D, Parkin M, Hirschhorn JN, Asselta R, Duga S, Musunuru K, Daly MJ, Purcell S, Eifert S, Braund PS, Wright BJ, Balmforth AJ, Ball SG; Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium; Cardiogenics, Ouwehand WH, Deloukas P, Scholz M, Cambien F, Huge A, Scheffold T, Salomaa V, Girelli D, Granger CB, Peltonen L, McKeown PP, Altshuler D, Melander O, Devaney JM, Epstein SE, Rader DJ, Elosua R, Engert JC, Anand SS, Hall AS, Ziegler A, O'Donnell CJ, Spertus JA, Siscovick D, Schwartz SM, Becker D, Thorsteinsdottir U, Stefansson K, Schunkert H, Samani NJ, Quertermous T. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol 2010;56:1552-63

Role: Co-Investigator (lead platelet biologist) on the GeneSTAR (Genetic Study of Aspirin Responsiveness) study that served as one of the cohorts included in the analysis.

 

  1. Vaidya D, Yanek LR, Herrera-Galeano JE, Mathias RA, Moy TF, Faraday N, Becker LC, Becker DM. A common variant in the Von Willebrand factor gene is associated with multiple functional consequences. Am J Hematol 2010;85:971-3

 

  1. Faraday N, Yanek LR, Yang XP, Mathias R, Herrera-Galeano JE, Suktitipat B, Qayyum R,  Johnson AD, Chen M-H, Tofler GH, Ruczinski I, Friedman AD, Gylfason A, Thorsteinsdottir U, Bray PF, O’Donnell CJ, Becker DM, Becker LC. Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression. Blood 2011; 118: 3367-3375

 

  1. Faraday N, Rock P, Lin EE, Perl TM, Carroll K, Stierer T, Robarts P, McFillin A, Ross T, Shah AS, Riley LH, Tamargo RJ, Black JH, Blasco-Colmenares E, Guallar E. Past history of skin infection and risk of surgical site infection after elective surgery. Ann Surg 2013 Jan;257(1):150-4.

 

  1. Lewis JP, Ryan K, O'Connell JR, Horenstein RB, Damcott CM, Gibson Q, Pollin TI, Mitchell BD, Beitelshees AL, Pakzy R, Tanner K, Parsa A, Tantry US, Bliden KP, Post WS, Faraday N, Herzog W, Gong Y, Pepine CJ, Johnson JA, Gurbel PA, Shuldiner AR. Genetic Variation in PEAR1 is Associated with Platelet Aggregation and Cardiovascular Outcomes. Circ Cardiovasc Genet. 2013 Apr;6(2):184-92.

 

  1. Kim Y, Suktitipat B, Yanek LR, Faraday N, Wilson AF, Becker DM, Becker LC, Mathias RA. Targeted Deep Resequencing Identifies Coding Variants in the PEAR1 Gene That Play a Role in Platelet Aggregation. PLoS One 2013;8(5):e64179. doi

 

  1. Faraday N, Jaques K, Saleem S, Fu J, Wang B, Zhang J, Morrell C, Dore S. Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils. PLoS One 2013;8(8):e71447. doi: 10.1371/journal.pone.0071447.

 

  1. Qayyum R, Becker DM, Yanek LR, Faraday N, Vaidya D, Mathias R, Kral BG, Becker LC. Greater Collagen-Induced Platelet Aggregation Following Cyclooxygenase 1 Inhibition Predicts Incident Acute Coronary Syndromes. Clin Transl Sci 2015;8(1):17-22..

 

  1. Schunke KJ, Toung TK, Zhang J, Pathak AP, Xu J, Zhang J, Koehler RC, Faraday N. A novel atherothrombotic model of ischemic stroke induced by injection of collagen into the cerebral vasculature. J Neurosci Methods 2015;239:65-74.

 

  1. Greilich PE, Edson E, Rutland L, Jessen ME, Key NS, Levy JH, Faraday N, Steiner ME. Protocol Adherence When Managing Massive Bleeding Following Complex Cardiac Surgery: A Study Design Pilot. J Cardiothorac Vasc Anesth. 2015;29(2):303-10.

 

  1. Qayyum R, Becker LC, Becker DM, Faraday N, Yanek LR, Leal SM, Shaw C, Mathias R, Suktitipat B, Bray PF. Genome-wide association study of platelet aggregation in African Americans. BMC Genet. 2015 May 30;16(1):58.

 

  1. Sajan F, Conte JV, Tamargo RJ, Riley LH, Rock P, Faraday N. Association of Selective Serotonin Reuptake Inhibitors with Transfusion in Surgical Patients. Anesth Analg. 2016 Jul;123(1):21-8.

 

  1. Chami N, Chen MH, Slater AJ, Eicher JD, Evangelou E, Tajuddin SM, Love-Gregory L, Kacprowski T, Schick UM, Nomura A, Giri A, Lessard S, Brody JA, Schurmann C, Pankratz N, Yanek LR, Manichaikul A, Pazoki R, Mihailov E, Hill WD, Raffield LM, Burt A, Bartz TM, Becker DM, Becker LC, Boerwinkle E, Bork-Jensen J, Bottinger EP, O'Donoghue ML, Crosslin DR, de Denus S, Dubé MP, Elliott P, Engström G, Evans MK, Floyd JS, Fornage M, Gao H, Greinacher A, Gudnason V, Hansen T, Harris TB, Hayward C, Hernesniemi J, Highland HM, Hirschhorn JN, Hofman A, Irvin MR, Kähönen M, Lange E, Launer LJ, Lehtimäki T, Li J, Liewald DC, Linneberg A, Liu Y, Lu Y, Lyytikäinen LP, Mägi R, Mathias RA, Melander O, Metspalu A, Mononen N, Nalls MA, Nickerson DA, Nikus K, O'Donnell CJ, Orho-Melander M, Pedersen O, Petersmann A, Polfus L, Psaty BM, Raitakari OT, Raitoharju E, Richard M, Rice KM, Rivadeneira F, Rotter JI, Schmidt F, Smith AV, Starr JM, Taylor KD, Teumer A, Thuesen BH, Torstenson ES, Tracy RP, Tzoulaki I, Zakai NA, Vacchi-Suzzi C, van Duijn CM, van Rooij FJ, Cushman M, Deary IJ, Velez Edwards DR, Vergnaud AC, Wallentin L, Waterworth DM, White HD, Wilson JG, Zonderman AB, Kathiresan S, Grarup N, Esko T, Loos RJ, Lange LA, Faraday N, Abumrad NA, Edwards TL, Ganesh SK, Auer PL, Johnson AD, Reiner AP, Lettre G. Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. Am J Hum Genet. 2016 Jul 7;99(1):8-21.

 

  1. Eicher JD, Chami N, Kacprowski T, Nomura A, Chen MH, Yanek LR, Tajuddin SM, Schick UM, Slater AJ, Pankratz N, Polfus L, Schurmann C, Giri A, Brody JA, Lange LA, Manichaikul A, Hill WD, Pazoki R, Elliot P, Evangelou E, Tzoulaki I, Gao H, Vergnaud AC, Mathias RA, Becker DM, Becker LC, Burt A, Crosslin DR, Lyytikäinen LP, Nikus K, Hernesniemi J, Kähönen M, Raitoharju E, Mononen N, Raitakari OT, Lehtimäki T, Cushman M, Zakai NA, Nickerson DA, Raffield LM, Quarells R, Willer CJ, Peloso GM, Abecasis GR, Liu DJ; Global Lipids Genetics Consortium, Deloukas P, Samani NJ, Schunkert H, Erdmann J; CARDIoGRAM Exome Consortium; Myocardial Infarction Genetics Consortium, Fornage M, Richard M, Tardif JC, Rioux JD, Dube MP, de Denus S, Lu Y, Bottinger EP, Loos RJ, Smith AV, Harris TB, Launer LJ, Gudnason V, Velez Edwards DR, Torstenson ES, Liu Y, Tracy RP, Rotter JI, Rich SS, Highland HM, Boerwinkle E, Li J, Lange E, Wilson JG, Mihailov E, Mägi R, Hirschhorn J, Metspalu A, Esko T, Vacchi-Suzzi C, Nalls MA, Zonderman AB, Evans MK, Engström G, Orho-Melander M, Melander O, O'Donoghue ML, Waterworth DM, Wallentin L, White HD, Floyd JS, Bartz TM, Rice KM, Psaty BM, Starr JM, Liewald DC, Hayward C, Deary IJ, Greinacher A, Völker U, Thiele T, Völzke H, van Rooij FJ, Uitterlinden AG, Franco OH, Dehghan A, Edwards TL, Ganesh SK, Kathiresan S, Faraday N, Auer PL, Reiner AP, Lettre G, Johnson AD. Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals. Am J Hum Genet. 2016 Jul 7;99(1):40-55.

 

  1. Tajuddin SM, Schick UM, Eicher JD, Chami N, Giri A, Brody JA, Hill WD, Kacprowski T, Li J, Lyytikäinen LP, Manichaikul A, Mihailov E, O'Donoghue ML, Pankratz N, Pazoki R, Polfus LM, Smith AV, Schurmann C, Vacchi-Suzzi C, Waterworth DM, Evangelou E, Yanek LR, Burt A, Chen MH, van Rooij FJ, Floyd JS, Greinacher A, Harris TB, Highland HM, Lange LA, Liu Y, Mägi R, Nalls MA, Mathias RA, Nickerson DA, Nikus K, Starr JM, Tardif JC, Tzoulaki I, Velez Edwards DR, Wallentin L, Bartz TM, Becker LC, Denny JC, Raffield LM, Rioux JD, Friedrich N, Fornage M, Gao H, Hirschhorn JN, Liewald DC, Rich SS, Uitterlinden A, Bastarache L, Becker DM, Boerwinkle E, de Denus S, Bottinger EP, Hayward C, Hofman A, Homuth G, Lange E, Launer LJ, Lehtimäki T, Lu Y, Metspalu A, O'Donnell CJ, Quarells RC, Richard M, Torstenson ES, Taylor KD, Vergnaud AC, Zonderman AB, Crosslin DR, Deary IJ, Dörr M, Elliott P, Evans MK, Gudnason V, Kähönen M, Psaty BM, Rotter JI, Slater AJ, Dehghan A, White HD, Ganesh SK, Loos RJ, Esko T, Faraday N, Wilson JG, Cushman M, Johnson AD, Edwards TL, Zakai NA, Lettre G, Reiner AP, Auer PL. Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases. Am J Hum Genet. 2016 Jul 7;99(1):22-39.

 

  1. Shah P, Yang W, Sun S, Pasay J, Faraday N, Zhang H. Platelet glycoproteins associated with aspirin-treatment upon platelet activation. Proteomics. 2017 Mar;17(6).

 

  1. Kammers K, Taub MA, Ruczinski I, Martin J, Yanek LR, Frazee A, Gao Y, Hoyle D, Faraday N, Becker DM, Cheng L, Wang ZZ, Leek JT, Becker LC, Mathias RA. Integrity of Induced Pluripotent Stem Cell (iPSC) Derived Megakaryocytes as Assessed by Genetic and Transcriptomic Analysis. PLoS One. 2017 Jan 20;12(1):e0167794.

 

  1. Eicher JD, Chen MH, Pitsillides AN, Lin H, Veeraraghavan N, Brody JA, Metcalf GA, Muzny DM, Gibbs RA, Becker DM, Becker LC, Faraday N, Mathias RA, Yanek LR, Boerwinkle E, Cupples LA, Johnson AD. Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation. Thromb Haemost. 2017 Jun 2;117(6):1083-1092.

 

  1. Chen MH, Yanek LR, Backman JD, Eicher JD, Huffman JE, Ben-Shlomo Y, Beswick AD, Yerges-Armstrong LM, Shuldiner AR, O'Connell JR, Mathias RA, Becker DM, Becker LC, Lewis JP, Johnson AD, Faraday N. Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation. Platelets. 2017 Nov 29:1-10.

 

  1. Chen L, Xu X, Zeng H, Chan KWY, Yadav N, Cai S, Schunke KJ, Faraday N, van Zijl PCM, Xu J. Separating fast and slow exchange transfer and magnetization transfer using off-resonance variable-delay multiple-pulse (VDMP) MRI. Magn Reson Med. 2018 Feb 5. doi: 10.1002/mrm.27111. [Epub ahead of print]

 

  1. Keramati AR, Yanek LR, Iyer K, Taub MA, Ruczinski I, Becker DM, Becker LC, Faraday N, Mathias RA. Targeted deep sequencing of the PEAR1 locus for platelet aggregation in European and African American families. Platelets. 2018 Mar 19:1-7. doi: 10.1080/09537104.2018.1447659. [Epub ahead of print]

 

  1. Al-Sofiani ME, Yanek LR, Faraday N, Kral BG, Mathias R, Becker LC, Becker DM, Vaidya D, Kalyani RR. Diabetes and Platelet Response to Low-dose Aspirin. J Clin Endocrinol Metab. 2018 Sep 27. doi: 10.1210/jc.2018-01254. [Epub ahead of print]

 

 

Review articles

 

  1. Faraday N. Pro: Should aspirin be continued post cardiac surgery in the setting of thrombocytopenia? J Cardiothorac Vasc Anesth 2006;20:112-3

 

  1. Faraday N, Becker DM, Becker LC. Pharmacogenomics of platelet responsiveness to aspirin. Pharmacogenomics 2007;Oct. 8(10): 1413-25

 

  1. Brown C, Joshi B, Faraday N, Shah A, Yuh D, Rade JJ, Hogue CW. Emergency Cardiac Surgery in Patients with Acute Coronary Syndromes: A Review of the Evidence and Perioperative Implications of Medical and Mechanical Therapeutics. Anesth Analg. 2011;112:777-99

 

  1. Pustavoitau A, Faraday N. Pro: Antifibrinolytics Should Be Used in Routine Cardiac Cases Using Cardiopulmonary Bypass (Unless Contraindicated). J Cardiothorac Vasc Anesth.2016 Jan;30(1):245-7.

 

Editorials/Letters

 

  1. Dorman T, Faraday N. Do gene variants really explain the heterogeneous outcomes in sepsis? Crit Care Med. 2001;29: 684-5

 

  1. Faraday N. Platelets, perioperative hemostasis, and anesthesia. Anesthesiology 2002;96:1042-3

 

  1. Faraday N. Review finds greater work is needed to define and assess the incidence of aspirin resistance. Evidence-based Cardiovasc Med 2004;8: 268-9

 

  1. Faraday N. Perioperative platelet activation and the inhibitory effect of milrinone. Anesthesiology 2009;111:1185-6

 

  1. Faraday N. Fibrinogen concentrate and allogeneic blood transfusion in high risk surgery. Anesthesiology 2013 Jan;118(1):7-9

 

  1. Faraday N. Balancing Thrombotic and Bleeding Risks Related to Antiplatelet Therapy in Coronary Bypass Surgery: Comment on "Protective Effects of Tranexamic Acid on Clopidogrel Before Coronary Artery Bypass Grafting". JAMA Surg 2013;148(6):548.

 

  1. Latif A, Faraday N. Use of hemodynamic algorithm after gastrointestinal surgery. JAMA 2014; 312:1470.

 

  1. Fan JR, Faraday N. Vasopressin versus Norepinephrine after Cardiopulmonary Bypass. Anesthesiology. 2018 Jan;128(1):229-230.

 

 

Book Chapters, Monographs

 

  1. Faraday N.  Thrombocytopenia. In Essence of Anesthesia Practice.  Roizen MF, Fleisher LA eds.  WB Saunders Company, Philadelphia; 2002.

 

  1. Haddadin AS and Faraday N. Postoperative management of the cardiac surgical patient. In The Johns Hopkins Manual of Cardiothoracic Surgery. Yuh DD, Vricella LA, Baumgartner WA, eds. McGraw-Hill Medical, New York; 2007

 

  1. Haddadin AS and Faraday N. Management of bleeding and tamponade. In The Johns Hopkins Manual of Cardiothoracic Surgery. Yuh DD, Vricella LA, Baumgartner WA, eds. McGraw-Hill Medical, New York; 2007

 

  1. Khan Y, Faraday N, Herzog W, Shuldiner AR. Genetic Determinants of Arterial Thrombosis. In Cardiovascular Genetics and Genomics. Roden DM, ed. Wiley-Blackwell Publishing, Boston; 2009.

 

  1. Faraday N.  Thrombocytopenia. In Essence of Anesthesia Practice, 3rd Edition.  Roizen MF, Fleisher LA eds.  WB Saunders Company, Philadelphia; 2011.

 

  1. Ginwalla R, Faraday N, Whitman G. Postoperative management of the cardiac surgical patient. In The Johns Hopkins Manual of Cardiothoracic Surgery. In The Johns Hopkins Manual of Cardiothoracic Surgery. Yuh DD, Vricella LA, Baumgartner WA, eds. McGraw-Hill Medical, New York; 2014.

 

  1. Pustavoitau A, Faraday N.  Thrombocytopenia. In Essence of Anesthesia Practice, 4th Edition.  Fleisher LA, Roizen MF, Roizen JR, eds.  Elsevier, Philadelphia; 2017.

 

Extramural Research Funding

 

Current Grant Support:

 

 

3/01/2018-2/30/19              Characterizing key factors influencing blood pressure variation and its relation to clinical outcomes in chronic diseases using large-scale connected health and clinical datasets

              Data Intensive Engineering and Science (IDIES) Seed Funding Program (SFP)

              $25,000

              PI: Nauder Faraday

              The goal of this project is to develop data analytics tools to visualize and interpret time-dependent vital signs data to: 1) Identify patients who experience significant variations in blood pressure for short (few minutes) and/or longer periods of time (several days). 2) Determine the relationship between variability in vital signs and clinical outcome. The overall goal of this work is to improve quality of medical care by using data analytics tools that can simplify complex data and better inform clinical decision making.

 

Previous Grant Support

 

9/96-8/01                            Examination of gender differences in GPIIb-IIIa function

                                          1 K08 HL03454-01A1

                                          NIH/NHLBI, Clinician Scientist Investigator Award

                                          $481,460; Annual Direct Cost:  $86,130 (9/96-8/99), $111,130 (adjusted 9/99-8/01)

                                          Role: Principal Investigator- 75% Effort

 

7/01-6/03                            Platelet polymorphisms and cardiovascular outcome in vascular surgical patients

                                          0160347U

                                          American Heart Association

                                          $120,000; Annual Direct Cost: $60,000

                                          Role: Principal Investigator- 13% Effort

 

9/01-8/04                            Coronary thrombosis and risk in the Emergency Department

                                          1R01HL69746-01

                                          NIH/NHLBI

                                          PI: G. Green

Role: Co-Investigator- 5% Effort; The goal of this study is to identify biomarkers of cardiovascular risk in chest pain patients who present to the emergency department.

 

8/01-8/02                            Relationship between whole blood hemostatometry and clinical hemostasis in cardiac surgery

                                          Xylum Corporation

                                          $50,000

                                          Role: Principal Investigator- 10% effort

 

2/02-2/03                            Platelet activation in women with acute coronary syndromes: Response to GPIIb-IIIa inhibition.

                                          Merck Pharmaceutical

                                          PI: S. Schulman

                                          Role: Co-Investigator

 

9/1/02 - 8/31/07                            TMH-Transfusion Medicine Hemostasis (Clinical Trials Network)

                                          5U01HL07219102

                                          NIH/NHLBI

                                          Annual Direct Cost (salary only): $269,981 (9/1/02- 8/31/07)

                                          PI: P. Ness

Role: Co-Investigator- 5% Effort; The goal of this project is to perform multi-center clinical trials in leading academic institutions in a variety of topics related to transfusion medicine and hemostasis.

 

10/1/02-12/31/09              Genotypic determinants of aspirin response in high risk families

                                          1U01 HL72518-01

                                          NIH/NHLBI

                                          $8,172,469; Annual Direct Cost: $1,502,935

                                          PI: L. Becker

Role: Co-Investigator- 40% Effort; The overall goal of this project is to identify gene variants that determine platelet response to low dose aspirin treatment in Caucasian and African American families.

 

9/05-9/10                            Pharmacogenomics of anti-platelet agents for CVD prevention

                                          U01 GM074518

                                          NIH/NIGMS

                                          $5,345,075; Annual Direct Cost: $965,142

                                          PI: A. Shuldiner

Role: Co-Investigator- 12% Effort; The goal of this project is to identify the genetic basis for variability in platelet responsiveness to clopidogrel in asymptomatic Amish families.

 

1/07- 1/08                            A Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Dose Escalation Trial on

                                          Safety and Efficacy of Activated Recombinant Factor VII (rFVIIa/NovoSeven) in

                                          the Treatment of Post-Operative Bleeding in Patients Following Cardiac Surgery

                                          Requiring Cardiopulmonary Bypass

                                          NovoNordisk

Role: Hopkins PI for multicenter study;  The goal of this study is to determine the safety and efficacy of rFVIIa for treatment of bleeding after cardiac surgery.

 

3/5/07- 2/28/10                            Genome-Wide Association of Platelet Phenotypes

                                          R01 HL097698

                                          NIH/NHLBI

                                          $2,814,832

                                          PI: L. Becker

Role: Co-Investigator- 2% Effort; The overall goal of this proposal is to identify genes that modify the function of platelets, both under “normal native” conditions, and following low dose aspirin.

 

9/30/09-8/31/12               Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders

                                          RC1 HL099677-01

                                          NIH/NHLBI-

                                          $500,285; Annual Direct Cost: $250,041

Role: PI, 17% Effort; The purpose of the proposed studies is to identify a key point in the communication between leukocytes and platelets that can serve as a target for novel pharmaceuticals that will prevent vascular occlusion despite vessel injury.

 

9/1/10- 1/30/13                            Pharmacogenomics of Anti-platelet Intervention-2 (PAPI-2) Study

                                          9U01 HL105198

                                          NIH/NHLBI

                                          $993,185/$9,668,175; Annual Direct Cost: $198,637 (Hopkins)/$1,933,635 (all sites)

                                          PI: A. Shuldiner

Role: Co-Investigator/ Site PI- 7% Effort; The PAPI-2 Study is a multi-center (5) randomized clinical trial comparing genotype-directed anti-platelet therapy versus standard of care anti-platelet therapy in patients undergoing percutaneous coronary intervention. The genotype-directed arm will receive clopidogrel 75 mg/day for those with the CYP2C19*1/*1 genotype or prasugrel 10 mg/day for those with the CYP2C19-/*2 genotype. The standard of care arm will consist of clopidogrel 75 mg/day regardless of genotype. Patients will be followed up at 3 month intervals for up to 1 year for adverse cardiovascular and bleeding events. The clinical and cost effectiveness of genotype directed anti-platelet therapy will be determined. DNA from all subjects will be used for genome-wide studies to identify rare variants that determine response to anti-platelet therapy.

 

6/1/13-5/30/16              Bacterial community composition and functional profiling of the nasal microbiota in relation to surgical site infection

              NIAID Genomic Sequencing Centers for Infectious Diseases- accepted white paper proposal

              $

              Role: Co-PI (with Emmanuel Mongodin). The goal of these studies is to examine the composition of microorganisms inhabiting the anterior nares , using 16S rRNA profiling, of patients scheduled to undergo high risk surgical procedures, and to determine the association between these microorganisms and development of surgical site infection in a prospective cohort study.

 

7/1/11-6/30/16                            Functional Genomics of Platelet Aggregation Using iPS and Derived Megakaryocytes

                                          RFA-HL-11-006

                                          NIH/NHLBI

                                          $507,929

                                          PI: L Becker

Role: Co-Investigator (2% effort years 1 and 2, 10% effort years 3 and 4, 40% effort year 5); In our GWAS study of platelet aggregation phenotypes before and after low dose aspirin in 2200 subjects (GeneSTAR), 64 and 57 loci were associated at genome-wise significance before and after aspirin, respectively. Mechanistic interpretation is limited by uncertainty as to which gene(s) are up- or downregulated based on SNP modifications. In 3 phases, we will (1) create pluripotent stem cells (iPS) from peripheral blood mononuclear cells, and then differentiate these stem cells into megakaryocytes, (2) efficiently produce iPS and megakaryocytes using a novel pooling method, and (3) produce iPS and megakaryocytes from 400 subjects in GeneSTAR (200 whites, 200 African Americans), selected based on specific hypotheses derived from GWAS signals in native and post aspirin platelet function; characterize genetic mRNA transcripts using a comprehensive Affymetrix exon array; measure protein expression for transcripts of interest using mass spectrometry; examine mRNA and protein expression patterns for each GWAS signal to determine the functional pathway(s) involved in native platelet phenotypes; and examine the functional genomics of variations in responsiveness to aspirin using a prior genotyped and phenotyped population. (Phase 1 and II, PI: Linzhao Cheng;Phase III PI: Lewis C. Becker, overall contact PI.)

 

7/1/11-6/30/18               Glycoconjugates and cardiovascular disease                                   

                                          P01HL107153

                                          NIH/NHLBI

                                          $1,512,097

                                          PI: GW Hart

Role: Co-Investigator, project 4 (10% effort); The main focus of this research is to apply emerging glycoproteomic and glycomic technologies in human platelets in order to identify the specific alterations in platelet glycoproteins and glycans that contribute to heightened platelet reactivity and to use this information to design novel anti-thrombotic agents that target glycoproteins and complex sugars to treat cardiovascular disease.

 

4/01/14-03/31/18              Gene Transcripts and Proteomics in Families with Platelet Hyperaggregation 

HL-2-118356

NIH/NHLBI

$495,998

              PI: L Becker

              Role: Co-Investigator (2% effort)

This study is focused on platelet aggregation in subjects from high risk families. The aims are to: (1) use a family-based design to discover genes differentially expressed in subjects with platelet hyperaggregation compared to controls, (2) leverage prior GWAS signals  to identify eQTLs associated with transcript expression to help prioritize transcripts/genes, and (3) to determine whether changes in gene expression in hyperaggregating platelets are reflected in changes in expressed proteins. This study will produce a complete quantitative inventory of all mRNA transcripts present in platelets, as well as a complete eQTL map of genetic loci responsible for transcript expression in platelets in both European and African Americans

 

8/1/2016-10/30/2017              Leukocyte Telomere Length and Risk of Infection after Surgery

                                          JHU/ACCM StAAR Transformative Award

                                          PI: N. Faraday

                                          $25,000

Role: PI. The proposed experiments will evaluate leukocyte telomere length (LTL) as a biomarker of susceptibility to development of postoperative infection in a cohort of 800 surgical patients in whom we have already collected blood specimens and characterized clinical outcomes

 

 

 

 

CLINICAL ACTIVITIES

 

Clinical Focus

I have two main areas of clinical focus- critical care medicine and cardiac anesthesiology. The majority of my clinical time has been spent in critical care areas, including the cardiac surgical ICU, adult surgical ICU, and Weinberg ICU. In my previous role as Co-Director of the Cardiac Surgical ICU, I led development of a clinical and teaching service at Johns Hopkins, which was one of the first of its kind and served as a model for cardiac surgical ICUs at Duke, University of Pennsylvania, and Vanderbilt.

 

Certification

 

Licensure

              Maryland State Medical License (D0041860, since 1992)

              US Controlled Substance Registration Certificate

              MD State Registration for Controlled Substances

              ACLS Provider (5/2007, 5/2009)

 

Specialty Boards

              Diplomate, American Board of Anesthesiology (1993)

              Diplomate, Subspecialty in Critical Care Medicine (1993)

             

 

Clinical Service Responsibilities

 

Cardiac Surgical ICU- 1994-2010

              -ICU Co-Director, 1994-2004

              -17-18 service weeks/year (1994-1997)

              -10-14 service weeks/year (1997-2000)

              -8-10 service weeks/year (2000-2010)

              -12-14 hour average/clinical day

              -7 contiguous days of service at a time, including 7 contiguous night calls

 

Surgical Intensive Care Unit Attending- 2011-present

              - 6-8 weeks/year- 2011- present

              -12-14 hour average/clinical day

              -7 contiguous days of service at a time, including 7 contiguous night calls

 

Cardiac OR Anesthesia Attending- 1994-2018

              - 1 month/year

              -12 hour average/clinical day

              -12-18 night calls/year

 

Clinical Program Building/Leadership

Cardiac Surgical ICU as above             

 

 

EDUCATIONAL ACTIVITIES

 

Educational focus

My teaching focuses on issues related to perioperative hemostasis and thrombosis, including mechanisms and management of perioperative bleeding, transfusion management, postoperative thrombotic complications (MI, stroke, VTE), and management of antithrombotic agents. I have participated in and then led one of the largest national meetings on the topic of perioperative medicine- the Johns Hopkins Perioperative Management Course- which draws 400-500 participants annually from across the US, Canada, and Puerto Rico. In addition, I have mentored a number of post baccalaureates, post-doctoral fellows and residents in laboratory, translational and clinical research projects related to platelet biology and thrombosis. More recently, I have served as a mentor in career development processes for faculty in the department of Anesthesiology and School of Medicine, providing guidance for promotions.

 

Teaching

 

Clinical Instruction

1992-2009              Johns Hopkins University, Department of Anesthesiology

                            Title: Anesthesia Resident Lecture Series

                            Role- Lecturer- 3-5/year

 

1993-2000              Johns Hopkins University School of Medicine, Department of Anesthesiology

                            Medical Student Anesthesiology Clinical Clerkship

                            Role- Lecturer- 3/year on ICU Management

 

1994-present              Johns Hopkins University, Department of Anesthesiology

                            Cardiac Anesthesia Lecture Series

                            Role- Lecturer- 2-4/year

 

1994-2010              Johns Hopkins University, Department of Surgery

                            Cardiac Surgical Intensive Care Resident Education Program

                            Role- Lecturer- 8-10/year

 

2009-2011              Johns Hopkins University, Department of Anesthesiology

                            Anesthesiology Resident Lecture Series

                            Role- Lecturer- 6-8 lectures/year

 

2012-present              Johns Hopkins University, Department of Anesthesiology, monthly resident journal club

                            Role- Program leader/lecturer- 10 sessions/year

 

 

CME Instruction

1997                            Johns Hopkins University Perioperative Management Course

                            Location: Marco Island, FL and Aspen, CO

                            Role- Lecturer

                                          “Perioperative management of the patient on aspirin and coumadin”

                                          “Postoperative DVT and PE: Prophylaxis and Treatment”

                                          “Perioperative renal dysfunction”

 

1998                            Johns Hopkins University Perioperative Management Course

                            Location: Marco Island, FL and Aspen, CO

                            Role- Lecturer

                                          “Perioperative management of the patient on aspirin and coumadin”

                                          “Postoperative DVT and PE: Prophylaxis and Treatment”

                                          “Perioperative renal dysfunction”

                                          “Complications of Cardiac Surgery”

 

1999                            Johns Hopkins University Perioperative Management Course

                            Location: Marco Island, FL and Aspen, CO

                            Role- Lecturer

                                          “Perioperative management of the patient on aspirin and coumadin”

                                          “Postoperative DVT and PE: Prophylaxis and Treatment”

                                          “Perioperative renal dysfunction”

                                          “Complications of Cardiac Surgery”

 

2000-2005              Johns Hopkins University Perioperative Management Course

                            Location: Marco Island, FL

                            Role- Course Co-Director and lecturer

                                          “Perioperative management of the patient on aspirin and coumadin”

                                          “Postoperative DVT and PE: Prophylaxis and Treatment”

                                          “Perioperative renal dysfunction”

                                          “Complications of Cardiac Surgery”

                                          “The preoperative patient with a pacemaker or AICD”

                                          “Mechanisms, monitoring and management of patients with CAD”

                           

2006-                            Johns Hopkins University Perioperative Management Course

                            Location: Marco Island, FL

                            Role- Course Director and lecturer

                                          “Perioperative management of antiplatelet agents                                                                                                                “Postoperative DVT and PE

                                          “Mechanisms and management of perioperative myocardial ischemia

                                          “Management of perioperative anemia, transfusion, and bleeding”

“Perioperative management of direct oral anticoagulant agents (DOACS)”

Under my direction the course has grown from ~400 participants each year to >500year. It is the largest course of its kind, second in attendance only to major meetings of national anesthesia and critical care societies.

 

Other Educational Media

 

Audio-Digest

2013                            Perioperative DVT and Pulmonary Embolism

 

 

 

Mentoring

 

Research Trainees

                            Elizabeth Martinez, MD, MHS (2000-2001)

                            Valerie Sera, MD (2001-2002)

                            Ala Haddadin, MD (2002-2003)

                            Robert Scharpf, MS  (2002-2005)

                            Kelly Chiles, MS (2003-2005)

                            Michelle Kerns, BA (2005-2006)

                            Elaina Lin, MD (2008-2009)

                            Kate (Jacques) Schunke, PhD (2010-2015)

                            Joshua Lewis, PhD (2011-2013)

                            Rehan Qayyum, MD (2012-2014)

                            Kelly Pate, DVM (2013-2014)

                            Farrah Sajan, MD (2014-2015)

                            Ali Sobhi Afshar, PhD (2018-2019)

                            Youn-Hoa Jung, MD (2018-2019)

 

Doctoral Thesis Committee Member              

                            Craig Morrell, DVM, PhD (1/2005)

                            Adam Fisch, MD, PhD (2014)

 

                           

Doctoral Thesis Advisor

                            Elena Blasco-Colmenares, MD, PhD (6/2008)

 

MPH Advisor/Capstone supervisor

                            Poorva Tomar, MD.MPH (5/2016)

                            Shinya Miura, MD, MPH (5/2017)

                            Rialda Kovacevic, MD MPH (5/2018)

                            Shikha Ghandi MD, MPH (5/2018)

 

Training Grant              T32 – Anesthesiology

 

 

Educational Program Building 

 

1995-2000                 Cardiac Surgical Intensive Care Unit Rotation

Role: Development and maintenance of didactic program for surgical residents and critical care fellows in Cardiac Surgical ICU

 

2014-present              Career development/mentorship

Role- mentor/advisor/resource for faculty in the Dept of Anesthesiology and throughout the SOM regarding the promotions process at Johns Hopkins

3-5 lectures/year for individual departments and/or SOM general sessions

 

 

RESEARCH ACTIVITIES

 

Research Focus

I have conducted laboratory and clinical cardiovascular research for >20 years, having received continuous funding as a PI or Co-I from the NIH and AHA during that time. My research has focused on identifying the molecular and genetic basis for inter-individual variability in platelet function and response to anti-platelet therapy and identifying the molecular mechanisms through which neutrophil-platelet interactions promote vascular thrombosis and resistance to aspirin treatment. My clinical research has focused on identification of novel markers and mechanisms for bleeding, thrombotic, and infectious complications after surgery. The overarching goal of all these projects is to identify novel determinants of disease that allow a precision guided approach to prevention and treatment of thrombosis and infection in high risk individuals.

 

Research Program Building/Leadership             

 

2005-present              Director, Perioperative Genetic/Precision Medicine, Dept of Anesthesiology. The program involves an ongoing prospective cohort study of surgical patients at high risk for bleeding, thrombosis, and infection. The goal of the program is to identify molecular markers, which include genetic, microbiome, and proteins, that allow risk stratification and precision guided therapeutics for prevention of common high morbidity events after surgery. The program is a multi-center collaboration with the U of MD and involves collaboration among the departments of Anesthesiology, Surgery, Orthopedics, Neurosurgery, Hospital Epidemiology and Infection Control, and Pathology.

 

2015-present              Director, Clinical Research, Dept of Anesthesiology. My role is to assemble and direct a team of individuals who design, execute, and analyze clinical research and QI projects for the department of Anesthesiology, with the goals of accelerating research productivity and career development of our faculty and improving patient care and efficiency. The team now consists of a biostatistician, a database manager, 4 research coordinators, and 5 research assistants and supports >70 research projects.

 

Inventions, Patents, Copyrights

 

12/23/04              US patent 2004/0260058-A1: Novel endothelially expressed DNAs and proteins, and their use

 

1/13/11   US patent 12/665,859: Novel antithrombotic agents and their methods of use

 

 

SYSTEM INNOVATION and QUALITY IMPROVEMENT ACTIVITIES

 

System innovation/QI focus

The focus of my systems and QI work is to harness the power of IT infrastructure to develop resources that facilitate faculty development and clinical research and Q/I activities.

 

2014-present              Role- Team leader for development of a web-based tool to facilitate annual faculty reviews by Anesthesiology Dept Chair/Division Directors. The Professional Development Review (PDR) tool was created by Anesthesiology IT staff and was successfully deployed to review all dept faculty/staff beginning FY16. Feedback from department leaders and faculty has been very positive. ACCM has shared the tool with other departments in the SOM and with the Dept of Anesthesiology at Beth Israel in Boston.

 

2014- present              As Vice-Chair for Faculty Development, I developed and publically posted our Dept process to evaluate faculty for promotional readiness, which includes a feedback and mentorship component for each faculty member

 

2015-present              Role- Team leader for development of an electronic clinical research project submission and tracking tool for the Department of Anesthesiology

 

2015-present              Role- Team leader for development, maintenance, and analysis of an Anesthesiology Dept clinical database that permits tracking of nationally recognized metrics of care quality. In partnership with Johns Hopkins Hospital QI leaders, we have developed a process to extract key data from the electronic health record and are creating the software algorithms that electronically identify our defined quality metrics in real-time 

 

 

ORGANIZATIONAL ACTIVITIES

 

Institutional Administrative Appointments

1994-2004              JHH Medical Director Cardiac Surgical ICU

1997-2005               JHH Critical Care Committee

1998-2009              Chairperson, JHH CPR Advisory Committee

1998-2009               Member, JHH Medical Care Evaluation Committee

1999- 2006              Anesthesia Department Clinical Research Review Committee

1999- Present              JHH Risk Management committees (varied ad hoc committees: e.g. root cause analysis committees; patient transport protocol committee, chairperson)

2007-Present              Member, JHU Continuing Medical Education Committee

2008-Present              Member, JHU Dept of Anesthesiology, Associate Professor Promotions Committee

2009-Present              Member, JHU Dept of Anesthesiology, Research Committee

2009- Present              Member, JHU School of Medicine Associate Professor Promotions Committee

2011-2012              Member JHH taskforce for guideline development on management of antithrombotic therapies in the perioperative period

2012-Present              Vice Chair, JHU School of Medicine Associate Professor Promotions Committee

2013-2016              Member, Office of Faculty Development, Senior Advisory Council

2014-Present              Chair, Mentoring and Promotions Committee for Instructor/Assistant Professor/Associate Professor, JHU Dept of Anesthesiology

2014-Present              Vice-Chair for Faculty and Staff Development, JHU Dept of Anesthesiology

2015-Present              Director, Clinical Research, JHU Dept of Anesthesiology

 

 

 

 

Editorial Activities

 

Editorial board appointments

2005-2009              Associate Editor: Anesthesiology

2009-2012              Associate Editor, 2nd term: Anesthesiology

2017-                            Thrombosis & Haemostasis: Research

 

Peer review journal activities

 

1995-present              Ad hoc reviewer for:

American Journal of Cardiology

American Journal of Physiology

Anesthesia and Analgesia

Anesthesiology

Blood

BMC Anesthesiology

British Journal of Clinical Pharmacology

Circulation

Diabetes/Metabolism Research Reviews

European Journal of Clinical Investigation

European Journal of Neurology

JAMA

Journal of Cellular and Molecular Medicine

Journal of Thrombosis and Thrombolysis

Platelets

PLoS One

Stroke

Thrombosis and Haemostasis

Thrombosis Research

 

 

Professional Societies

1988-Present              Member, American Medical Association

1988-Present              Member, Alpha Omega Alpha Honor Society

1989-Present              Member, American Society of Anesthesiologists

1989-Present              Member, International Anesthesia Research Society

1992-Present              Member, Society of Critical Care Medicine

1993-Present              Member, Society of Cardiovascular Anesthesiologists

 

 

RECOGNITION

 

Awards, Honors

1988                            Alpha Omega Alpha Medical Honor Society

1988                            Upjohn Achievement Award for Clinical Excellence

2002                            Association of Cardiac Anesthesiologists- invited membership

2003                            Association of University Anesthetists- invited membership

2005                            Johns Hopkins Leadership Development Program Nominee

2011                            Marquis Who’s Who in Medicine and Healthcare

2014                            Johns Hopkins Dept of Anesthesiology- Resident Teaching Award

2014                            Anesthesiology- Top 10% of journal reviewers

 

 

Advisory Committees, Review Groups/Study Sections

2005                            NIH/NHLBI Special Emphasis Panel: SCCOR in Hemostatic and Thrombotic Diseases

2012                            AHA/Brain-Experimental Models in Vascular Stroke Review Study Section

2013                            AHA/Stroke- Basic Science Study Section

 

 

Consultant

2014-2017              CSL Behring

 

Invited Talks             

3/97                            University of Pennsylvania, Department of Anesthesiology Grand Rounds - “Hematologic

                            Complications of Cardiopulmonary Bypass”

5/98                            Society of Cardiovascular Anesthesiologists Annual Meeting - Update on CPB- “New Antithrombotic Agents:  Pharmacology and Implications for the Management of Cardiac Surgical Patients”

6/01                            Johns Hopkins University, Department of Anesthesiology Grand Rounds - “Platelet genes and cardiovascular outcome in vascular surgery”

8/01                            Johns Hopkins University, Department of Medicine/Hematology Grand Rounds - “Platelet genes and cardiovascular outcome in vascular surgery”

10/01                            Association of Cardiac Anesthesiologists Annual Meeting- “Platelet genes and cardiovascular outcome”

5/02                            Johns Hopkins University, Department of Anesthesiology Research Conference - “Influence of leukocytes on platelet function”

10/02                            Association of Cardiac Anesthesiologists Annual Meeting - “Genetic determinants of perioperative myocardial ischemia”

11/02                            Duke University, Dept of Anesthesiology Research Conference - “Platelet polymorphisms as risk factors for perioperative myocardial ischemia”

5/03                            Society of Cardiovascular Anesthesiologists Annual Meeting - “Platelet polymorphisms and cardiovascular risk in vascular surgery”

4/05                            Johns Hopkins University, Neurosciences Critical Care Grand Rounds - “Prevalence and Risk                                           Factors for Aspirin Resistance”

5/06                            Johns Hopkins University, Hematology Grand Rounds - “Variability in Platelet Aspirin Responsiveness”

6/06                            Johns Hopkins University, Pathology Grand Rounds - “Variability in Platelet Aspirin Responsiveness”

4/07                            Johns Hopkins University, Comparative Medicine Research Seminar - “Variability in Platelet Aspirin Responsiveness”

6/08                            Society of Cardiovascular Anesthesiologists Annual Meeting (Vancouver, BC) - “Variability in platelet response to aspirin: Implications for perioperative management”

5/09                            Washington Hospital Center (Washington, DC)- Cardiology/Cardiac Catheterization Conference

“Aspirin Plus Clopidogrel and Risk of Infection after Coronary Artery Bypass Surgery”

9/11                            Suburban Hospital (Bethesda, MD)- Grand Rounds; “Perioperative Management of Anti-Platelet Therapy”

1/12                            Mercy Medical Center (Baltimore, MD)- Surgery/Anesthesiology Combined Grand Rounds, “Perioperative Management of Anti-Platelet Therapy”

1/12                            University of Florida (Gainesville, FL)- Anesthesia Department Research Conference, “Neutrophil Cathepsin G, Platelet Activation, and Thrombus Formation In Vivo”

4/13                            Washington Hospital Center (Washington, DC)- Anesthesia Department Grand Rounds, “Management of Perioperative Bleeding and Transfusion”

12/13                            Johns Hopkins University (Baltimore, MD), Dept of Cardiology, “Perioperative Management of Anti-Platelet Therapy”

4/14                            Reading Hospital (Reading, PA), Dept of Medicine Grand Rounds, “Perioperative Management of Anti-Platelet Therapy”

8/14                            Johns Hopkins University (Baltimore, MD), Dept of Anesthesiology Grand Rounds, “Perioperative Management of Anti-Platelet Therapy”

9/14                            Doctors Hospital at Renaissance (South Padre Island, TX), Annual Medical Conference, “Perioperative Management of Anti-Platelet Therapy”

5/18                            Johns Hopkins Topics in Clinical Medicine (Baltimore, MD). “Peri-procedural management of anti-thrombotic therapy”

1